2 Rho-kinase as a Novel Therapeutic Target for the Treatment of Inflammatory and Arteriosclerotic Vascular Diseases : From Bench to Bedside(Plenary Session 2 (PL2) (IHD) : Inflammation and Atherosclerosis : From Bench to Bedside)(Special Program)
スポンサーリンク
概要
- 論文の詳細を見る
- 社団法人日本循環器学会の論文
- 2004-03-01
著者
-
Shimokawa Hiroaki
Department of Cardiology, Tohoku University School of Medicine
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Shimokawa Hiroaki
Department Of Cardiology Tohoku University School Of Medicine
関連論文
- New Prognostic Factors for Pulmonary Hypertension
- Double-Blind and Placebo-Controlled Study of the Effectiveness and Safety of Extracorporeal Cardiac Shock Wave Therapy for Severe Angina Pectoris
- PJ-302 High-Resolution Measurement of Carotid Artery Wall Elasticity for Clinical Tailor-Made Risk Management of Arteriosclerosis(Atherosclerosis, clinical-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Treatment with Eicosapentaenoic Acid Improves Exercise-Induced Vasodilation in Patients with Coronary Artery Disease
- Guidelines for Diagnosis and Treatment of Patients With Vasospastic Angina (Coronary Spastic Angina) (JCS 2008) : Digest Version
- Trends in Acute Myocardial Infarction Incidence and Mortality Over 30 Years in Japan : Report From the MIYAGI-AMI Registry Study
- Evidence for Rho-Kinase Activation in Patients With Pulmonary Arterial Hypertension
- PJ-477 Diagnostic Usefulness of Vasodilator Test with Inhaled Nitric Oxide in Patients with Pulmonary Veno-Occlusive Disease(PJ080,Pulmonary Circulation 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society
- PE-445 Renin-Angiotensin System Plays an Important Role in Diabetes Mellitus-Induced Diastolic Dysfunction in Hypertensive Rats(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulati
- PE-444 Prognostic Impact of Myocardial Fibrosis in Systolic Heart Failure : New Aspect of Usefulness of Myocardial Biopsy(PE075,Heart Failure (Pathophysiology) (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Soc
- PE-349 Gender Difference in the Responsiveness to Corticosteroid Therapy in Patients with Cardiac Sarcoidosis(PE059,Heart Failure (Treatment) 2 (M),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-129 Genetic Deletion of OX40 Ligand Suppresses the Development of Atherosclerosis in Apolipoprotein E-Deficient Mice(PE022,Atherosclerosis, Basic (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Optical Coherence Tomography as a Novel Diagnostic Tool for Distal Type Chronic Thromboembolic Pulmonary Hypertension
- 1 Current Status of Vasospastic Angina in Japan : An Interim-report of the Multicenter Registry of the Coronary Spasm Association of Japan(Recent Progress in the Management of Vasospastic Angina,Meet the Expert 6 (ME-6) (IHD),The 73rd Annual Scientific Me
- 2 Microvascular Angina : Invisible but Important Player in Cardiovascular Gender Medicine(Recent Progress of Gender-specific Medicine in Cardiology,Meet the Expert 4 (ME-4) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Lamin A/C Gene Mutations in Familial Cardiomyopathy with Advanced Atrioventricular Block and Arrhythmia
- Importance of Dual Induction Tests for Coronary Vasospasm and Ventricular Fibrillation in Patients Surviving Out-of-Hospital Cardiac Arrest
- 1 Importance of Medical Treatment for Vasospastic Angina : Lessons from Multicenter Registry by Coronary Spasm Association of Japan(Therapeutic Decision Making for Coronary Artery Disease Among PCI, CABG, and Medication,Symposium 3 (SY-03) (IHD),The 73rd
- Electrophysiological Properties of the Right Atrial Septum in Patients with Atrial Tachyarrhythmias
- OJ-261 Hydrogen Peroxide Derived from Beating Heart Mediates Coronary Microvascular Dilatation during Tachycardia in Dogs in Vivo(Coronary circulation, basic/clinical-2 (IHD) OJ44,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting
- OE-218 Risk Factors and Incidence of Pulmonary Embolism in Japan 2004(Thromboembolism/Antithrombotic therapy/Thrombolysis-1 (H) OE37,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Diabetes mellitus accelerates left ventricular diastolic dysfunction through activation of the renin-angiotensin system in hypertensive rats
- PJ-171 Pravastatin Ameliorates Hypoxia-Induced Pulmonary Arterial Hypertension Through Down-regulation of Stromal Cell-Derived Factor-1 in Mice(Pulmonary circulation(03)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circul
- Prognostic Importance of Chronic Kidney Disease in Japanese Patients With Chronic Heart Failure : Implications of the CHART Study
- PE-483 Prognostic Impact of Central Sleep Apnea in Patients with Chronic Heart Failure(Heart failure, clinical-9 (M) PE81,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-385 End-tidal Carbon Dioxide Predicts the Responsiveness of Patients with Chronic Heart Failure Associated with Central Sleep Apnea to Oxygen Therapy(Heart failure, clinical-6 (M) OJ65,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific
- OJ-247 Chronic Hypoxia Mobilizes Smooth Muscle Progenitors in Mice(Vascular smooth muscles-1 (H) OJ42,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-103 Therapeutic Importance of Angiotensin-Converting Enzyme Inhibitor and/or Angiotensin Receptor Blocker in Patients with Diastolic Heart Failure(Heart failure, clinical-4 (M) OJ18,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Me
- OE-168 Hemoglobin Level Predicts Sudden Death in Patients with Diastolic Heart Failure(Heart failure, clinical-1 (M) OE28,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 1 Accumulated Risks and Non-Optimum Medical Treatment in Japanese Older Patients with Chronic Heart Failure : Results from the CHART Study(Characteristics and Management Strategies of Chronic Heart Failure in the Japanese,Symposium 12 (SY12) (M),The 70th
- PE-171 Co-existence of Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest(PE029,Cardiopulmonary and Critical Care/ACLS (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Ci
- PE-004 Significance of Basal Coronary Artery Tone in Patients with Vasospastic Angina : Analysis by Using Quantitative Coronary Angiography(Angina pectoris, basic/clinical(03)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese
- OE-393 Importance of Dual Induction Test for Coronary Vasospasm and Ventricular Fibrillation in Patients Survived from Out-of-Hospital Cardiac Arrest(Emergency care/CPR(01)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese C
- PJ-759 Equivalent Inhibitory Effects of 4.0-mm-Diameter Bare Metal Stent with 3.5-mm-Diameter Drug-eluting Stent to Prevent Restenosis after Percutaneous Coronary Intervention(Coronary revascularization, PCI-22, The 71st Annual Scientific Meeting of the J
- PJ-329 Low-dose of Thyroid Hormone Restores Depressed Contractility and Impaired Calcium Handling in Chronically Unloaded Heart in Rats(Cardiac function, basic/clinical-4 (M) PJ56,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of
- Extracorporeal Shock Wave Therapy as a New and Non-invasive Angiogenic Strategy
- PJ-731 Genetic Disruption of All Nitric Oxide Synthase Isoforms Causes Accelerated Renal Lesion Formation in Mice in Vivo(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Soc
- PJ-693 Inhibition of Sodium Channels Enhances Arrhythmogenic Regional Endocardial Substrate in Patients with Brugada Syndrome(PJ116,Ventricular Arrhythmia (Clinical/Pathophysiology) (A),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The J
- PJ-533 Role of H_2O_2 as an Endogenous EDHF during Coronary Occlusion and Injection of Erythropoietin in Canine Coronary Native Collateral Microvessels(PJ090,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Poster Session (Japanese),Th
- PJ-234 Usefulness of Cardiac Magnetic Resonance Imaging to Evaluate Cardiac Dyssynchrony in Patients with Chronic Heart Failure(PJ040,CRT/ICD 2 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-188 Combination Therapy with an Angiotensin Receptor Blocker and a Calcium Channel Blocker Improves EDHF-Mediated Responses in Diabetic Apolipoprotein E-Deficient Mice(PJ032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) 1 (H),Poster
- PE-451 Extracorporeal Cardiac Shock Wave Therapy Ameliorates Left Ventricular Remodeling after Myocardial Ischemia-Reperfusion Injury in Pigs in Vivo(PE076,Regeneration (M),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circul
- OJ-046 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension(OJ08,Pulmonary Circulation (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 3 Evidence for Rho-kinase Activation in Patients with Pulmonary Arterial Hypertension(Young Investigator's Award for International Students Finalists Lecture (YIA International),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- 5 Differential Roles of Progenitor Cells in the Arterial Development of the Abnormal Vasculature(Young Investigator's Award Finalists Lectures (YIA),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-298 Cyclophilin A Promotes Vascular Oxidative Stress and Accelerates Development of Angiotensin II-induced Aortic Aneurysms(OE51,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Oral Presentation (English),The 73rd Annual Scientific
- OE-234 Cyclophilin A is a Novel Pro-Inflammatory Cytokine that Accelerates Development of Atherosclerosis(OE40,Atherosclerosis, Basic 2 (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- FRS-092 Cyclophilin A Promotes Angiotensin II-Induced Inflammation and Cardiovascular Hypertrophy in Mice(FRS19,Genetic Abnormalities in Cardiac Hypertrophy and Cardiomyopathy (M),Featured Research Session (English),The 73rd Annual Scientific Meeting of T
- OE-100 Role of Rho-kinase in the Pathogenesis of Coronary Hyperconstricting Responses Induced by Paclitaxel-Eluting Stent(OE17,Coronary Revascularization, PCI (Restenosis/Others/DES) (IHD),Oral Presentation (English),The 73rd Annual Scientific Meeting of
- Identification of endothelium-derived hyperpolarizing factor : an evolving concept on endothelium-derived relaxing factors
- OE-107 Long-Term Inhibition of Rho-Kinase Suppresses Left Ventricular Remodeling After Myocardial Infarction in Mice(Heart Failure, Basic 1 (M) : OE13)(Oral Presentation (English))
- Disruption of Inducible Nitric Oxide Synthase Improved Beta-Adrenergic Inotropic Responsiveness but not the Survival of Cytokine-Induced Cardiomyopathy
- PE-090 Overexpression of iNOS in RVLM causes hypertension and sympatho-excitation via an increase in oxidative stress(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))
- PE-089 Pressor response induced by central infusion of angiotensin II is mediated by activation of the Rho/Rho-kinase pathway in vivo(Autonomic Nervous System 1 (H) : PE16)(Poster Session (English))
- OE-267 Inhibition of endogenous Rho-kinase in the NTS enhances baroreflex control of heart rate in conscious rats(Autonomic Nervous System 3 (H) : OE33)(Oral Presentation (English))
- 3 Protective Role of Endogenous Erythropoietin-erythropoietin Receptor System in the Development of Heart Failure(The Mechanism and Management of Cardio-renal Risk,Roundtable Discussion 3 (RT-3) (H),The 73rd Annual Scientific Meeting of The Japanese Circu
- Emerging Problems of Heart Failure Practice in Japanese Women : Lessons From the CHART Study
- PE-337 Inhibition of Rho-kinase Ameliorates Diastolic Heart Failure in Hypertensive Rats(Heart failure, basic(03)(M),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-135 Diabetes Mellitus Accelerates Left Ventricular Diastolic Dysfunction through Activation of Renin-angiotensin System in Hypertensive Rats(Cardiac function, basic/clinical(01)(M),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Ja
- 9 Large Cohort Studies for the Establishment of Guidelines of Chronic Heart Failure in Japan(Symposium 18 (SY-18) (H) How can we Make the Best Use of Japanese Evidences for Future Guidelines,Special Program,The 72nd Annual Scientific Meeting of the Japane
- 4 Potential Roles of Anemia and Endogenous Erythropoietin-mediated Signaling in Cardiorenal Syndrome with Hypertension(Symposium 11 (SY-11) (M) Stroke and Cardiorenal Complications in Hypertension,Special Program,The 72nd Annual Scientific Meeting of the
- PJ-834 Identification of Non-Invasive Predictors of High-risk Patients with Pulmonary Arterial Hypertension(Pulmonary circulation-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-436 Rho-kinase Pathway Plays an Important Role in the Pathogenesis of Diastolic Heart Failure in Dahl Salt-Sensitive Hypertensive Rats(Heart failure, basic-4, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-319 Usefulness of Three-Dimensional Analysis with Multi-Detector Row Computed Tomography in the Treatment of Atrial Fibrillation(CT/DSA-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-348 Reverse Remodeling after Cardiac Resynchronization Therapy Influences Cardiac Events due to Heart Failure but not Ventricular Arrhythmias(Heart failure, clinical-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-345 Determinants of Left Ventricular Reverse Remodeling after Cardiac Resynchronization Therapy : Evaluation Using Quantitative Gated Myocardial Perfusion SPECT(Heart failure, clinical-03, The 71st Annual Scientific Meeting of the Japanese Circulation
- OE-205 Impact of Diabetes Mellitus on Left Ventricular Diastolic Dysfunction in Dahl Salt-Sensitive Hypertensive Rats(Cardiac function, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- FRS-068 Deletion of Endogenous Erythropoietin System in Non-Hematopoietic Cells Impairs Development of Coronary Angiogenesis and Enhances Susceptibility to Pressure-Overload-Induced Heart Failure(Heart Failure, Cardiac Remodeling and Cardiomyopathy 1, The
- FRS-026 Prognostic Importance of Estimated Glomerular Filtration Rate in Patients with Chronic Heart Failure(Clinical Heart Failure-Pathophysiology and Treatment, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 3 A New Approach with a Combined Cohort Study and Randomized Controlled Trials : Lessons from the CHART Study(Clinical Trials Update in Japan and Future Perspective, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-497 Prevalence of Lamin A/C Gene Mutations in the Familial Dilated Cardiomyopathy with Progressive AV Block in Northern Japan(Cardiomyopathy, basic/clinical-6 (M) PJ84,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japa
- OJ-175 High-Dose Statin Therapy Ameliorates Hypoxia-Induced Pulmonary Hypertension through Suppression of the SDF-1/CXCR4 Axis(Pulmonary circulation-2 (H) OJ30,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Cir
- PJ-249 Crucial Role of H_2O_2 as an Endogenous EDHF and Erythropoietin during Acute Coronary Occlusion in Canine Collateral Microvessels in Vivo(Coronary circulation, basic/clinical(03)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of t
- OJ-060 Role of Cu, Zn-SOD in the Synthesis of Endothelium-Derived Hyperpolarizing Factor (EDHF) during Reactive Hyperemia in Mouse Mesenteric Microcirculation in Vivo(Endothelium-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-143 Role of Endogenous Hydrogen Peroxide in Tachypacing-Induced Metabolic Coronary Vasodilatation in Canine Coronary Microcirculation in Vivo(Coronary circulation, basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society
- PE-558 Cardioprotective Role of Hydrogen Peroxide as an Endogenous EDHF during Ischemia-reperfusion Injury in Canine Coronary Microvessels in Vivo(Coronary circulation, basic/clinical-3 (IHD) PE95,Poster Session (English),The 70th Anniversary Annual Scien
- OE-211 Crucial Role of Hydrogen Peroxide as an Endogenous EDHF during Pacing-Induced Metabolic Dilatation in Canine Coronary Microvessels in Vivo(Coronary circulation, basic/clinical-1 (IHD) OE36,Oral Presentation (English),The 70th Anniversary Annual Sci
- OE-203 Important Role of Cu/Zn-SOD in the Synthesis of Endothelium-Derived Hyperpolarizing Factor during Reactive Hyperemia in Mouse Mesenteric Microvessels in Vivo(Endothelium-1 (H) OE34,Oral Presentation (English),The 70th Anniversary Annual Scientific
- Beneficial Role of Hydroxyfasudil, a Specific Rho-kinase Inhibitor, on Ischemia-Reperfusion Injury in Canine Coronary Microvessels in Vivo(Endothelial Function (H), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OE-128 Myocardial Protective Role of Hydrogen Peroxide, an Endogenous EDHF, in Coronary Autoregulation in Canine Subepicardial Microcirculation in Vivo(Coronary Circulation, Basic/Clinical 2 (IHD) : OE15)(Oral Presentation (English))
- FRS-055 Beneficial Role of Hydroxyfasudil, a Specific Rho-kinase Inhibitor, on Ischemia-Reperfusion Injury in Canine Coronary Microvessels(Oxidative Stress, Autonomic Function and Peripheral Vascular Diseases (H) : FRS7)(Featured Research Session (English
- 5 Current Status and Future Perspectives of Diastolic Heart Failure in Japan : Possible Importance of Metabolic Syndrome(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annual Scie
- PJ-055 Cardiac Resynchronization Therapy Homogenizes Non-uniform Regional Left Ventricular Wall Thickening Evaluated by Quantitative Gated Myocardial Perfusion SPECT(Heart failure, clinical-18 (M) PJ10,Poster Session (Japanese),The 70th Anniversary Annual
- OJ-318 Important Role of Endogenous Erythropoietin System to Recruit Endothelial Cells in Hypoxia-Induced Pulmonary Hypertension in Mice(Growth factor/Cytokine-1 (H) OJ53,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the J
- OJ-245 Molecular Mechanism for the Protective Effect of Endogenous Erythropoietin-Erythropoietin Receptor System against Myocardial Ischemia/Reperfusion Injury(Myocardial ischemia-reperfusion, basic/clinical-2 (M) OJ41,Oral Presentation (Japanese),The 70t
- OJ-184 Impaired Mobilization and Incorporation of Progenitor Cells into the Ischemic/Hypoxic Tissues in Erythropoietin Receptor-Knockout Mice(Regeneration (angionenesis/myocardial regeneration)-3 (M) OJ31,Oral Presentation (Japanese),The 70th Anniversary
- OJ-168 Important Protective Role of Endogenous Erythropoietin System in Ischemic Cardiovascular Disease(Endothelium-2 (H) OJ28,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-076 Usefulness of Quantitative Gated Myocardial Perfusion SPECT to Predict Left Ventricular Reverse Remodeling after Cardiac Resynchronization Therapy(Heart failure, clinical-3 (M) OJ13,Oral Presentation (Japanese),The 70th Anniversary Annual Scientifi
- OE-130 Important Protective Role of Endogenous Erythropoietin System against Pressure Overload-Induced Left Ventricular Dysfunction in Mice in Vivo(Heart failure, basic-1 (M) OE22,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting
- 2 Deficiency of Erythropoietin Receptor Gene in Non-hematopoietic Lineage Deteriorates Cardiac Function and Survival in Ventricular Pressure Overload in Mice(Molecular Mechanism of Hypertensive Heart Failure,Symposium 5 (SY5) (H),The 70th Anniversary Annu
- Impact of Sex and Age on Coronary Basal Tone
- OJ-278 Functional upregulation of bradykinin type-1 receptor in the coronary microciculation in patients with heart failure(Coronary Circulation, Basic/Clinical 3 (IHD) : OJ33)(Oral Presentation (Japanese))
- Intravenous Administration of a Rho-Kinase Inhibitor, Fasudil, Reduces Pulmonary Vascular Resistance In Patients with Pulmonary Hypertension
- Inhibition of Rho-Kinase with Fasudil Ameliorates Pacing-Induced Myocardial Ischemia in Patients with Effort Angina
- Intracoronary fasudil prevents myocardial ischemia in patients with angina and normal coronary arteriograms
- Suppression of coronary artery spasm by Rho-kinase inhibitor in patients with vasospastic angina
- Coronary microvascular disease in humans : endothelial vs. smooth muscle dysfunction
- Combination Therapy With Olmesartan and Azelnidipine Improves EDHF-Mediated Responses in Diabetic Apolipoprotein E-Deficient Mice
- 1 Central Obesity is a Significant Risk Independent of Insulin Resistance in the Development of Cardiovascular Disease(Key Players of Metabolic Syndrome,Symposium 4 (SY-04) (M),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OJ-068 JTV-519 Reverses Abnormal Ca2+ Release and Ca2+ Waves in Purkinje Cells from the Infarcted Canine Heart(Arrythmia, basic(02)(A),Oral Presentation(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)