高度の低圧低酸素環境下持久性トレーニングのラット骨格筋の酸化能に及ぼす影響

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The effects of endurance training under severe hypobaric hypoxia (380 Torr, simulated by hypobaric chamber) on oxidative capacity (activities of cytochrome oxidase and citrate synthase) of skeletal muscles were studied on rats. Male Wistar rats were randomly assigned to one of four groups : NC group (Normoxic control), HC group (Hypoxic control), NT group (Normoxic training), and HT group (Hypoxic training). Rats of NT and HT group were forced to run at 23m/ min on 6° inclined treadmill, 1h per day, 5 days per week, for 4 weeks under normoxic and hypoxic environment, respectively. Rats of HC and HT group were exposed to hypoxic environment for 12 h per day, for 4 weeks. Rats were pair-fed and water was supplied ad lib. Hypoxia decrease oxidative capasity of tibialis anterior muscle but not soleus muscle in sedentary groups. In soleus muscle, endurance training increased oxidative capasity under both normoxic and hypoxic environment. In tibialis anterior muscle, however, endurance training increased oxidative capacity under only normoxic environment. These results suggested that endurance training under severe hypobaric hypoxia could improve oxidative capacity of skeletal muscle partly in soleus, but not in tibialis anterior muscle of rats.
1995-01-31