On-Line Monitoring of Representative Structural Variables in Fed-Batch Cultivation of Recombinant Escherichia coli for Phenylalanine Production
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概要
- 論文の詳細を見る
During cultivation, the cell population often undergoes severe physiological transformations which can be interpreted as structural alterations in the process. In such cases, adequate control can be achieved only after accunting for these phenomena. A natural basis for accomplishing this task(often called diagnostics)is offered by pattern recognition theory. Practivally, its application requires selection and calculation of a set of variables, jointly capable of describing the structural state of the process. This set can be used consequently to monitor the process structural alterations, allowing the control system to react in a timely and suitable manner. Because of the well-known characteristics of biological processes, the problem of selection of representative structural variables is far from being trivial, and requires special attention. Here we present our experience in the definition and calculation of such variables in the fer-batch cultivation of recombinant Escherichia coli for phenylalanine production.
- 社団法人日本生物工学会の論文
- 1990-12-25
著者
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Konstantinov Konstantin
International Center Of Cooperative Research In Biotechnology Osaka University:(present Address)mile
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Konstantinov Konstantin
International Center Of Cooperative Research In Biotechnology Eaculty Of Engineering Osaka Universit
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YOSHIDA TOHIOMI
International Center of Cooperative Research in Biotechnology, Eaculty of Engineering, Osaka Univers
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Yoshida Tohiomi
International Center Of Cooperative Research In Biotechnology Eaculty Of Engineering Osaka Universit
関連論文
- A Mass Spectrometry Membrane Probe and Practical Problems Associated with Its Application in Fermentation Processes
- 519 Control of Acetic Acid Accumulation during Cultivation of Recombinant E__-. coli AT2471.
- Physiologically Motivated Strategies for Control of the Fed-Batch Cultivation of Recombinant Escherichia coli for Phenylalanine Production
- An Expert Approach for Control of Fermentation Processes as Variable Structure Plants
- On-Line Monitoring of Representative Structural Variables in Fed-Batch Cultivation of Recombinant Escherichia coli for Phenylalanine Production