Analysis of ZAPs, Zymogen Granule Membrane Associated Proteins, in the Regulated Exocytosis of the Pancreas

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概要

• 論文の詳細を見る

• To characterize molecules involved in the intracellular sorting and regulated exocytosis of digestive enzymes in the pancreas, proteins that are speciticially associated with the zymogen granule membranes were analyzed. Zymogen granules, the major secretory organelles in the pancreas, were highly puritied. SDS-PAGE analysis found at least 7 protein components in the zymogen granule membranes including ZAP (zymogen granule membrane associated protein) 75, 54, 47, 36, 32, 29, 25 (numbers refer to their apparent kDas). ZAP75 is identical to the glycophosphatidylinositol (GPI)-anchored protein, GP2. Partial amino acid sequencing of ZAP47 and ZAP36 found similarities to a preprocarboxypeptidase B and annexins, respectively. The method we used was a useful tool for structural analysis of the members of ZAPs.

• 社団法人日本農芸化学会の論文
• 1994-07-23

著者

• FUKUOKA Shin-Ichi

  Research Institute for Food Science, Kyoto University

• Fukuoka S

  Kyoto Univ. Kyoto Jpn

• Fukuoka Shin-ichi

  Research Institute For Food Science Kyoto University

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• Increase in Lysophosphatidylethanolamine in the Cell Membrane upon the Regulated Exocytosis of Pancreatic Acinar AR42J Cells
• Analysis of ZAPs, Zymogen Granule Membrane Associated Proteins, in the Regulated Exocytosis of the Pancreas

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