Candesartan Cilexetil Improves Left Ventricular Function, Left Ventricular Hypertrophy, and Endothelial Function in Patients With Hypertensive Heart Disease
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概要
- 論文の詳細を見る
Patients with hypertension often develop left ventricular (LV) hypertrophy and deterioration of the cardiac and endothelial functions. Recent clinical trials have shown the added benefits of angiotensin II receptor blockers in hypertensive patients. Twenty-nine patients with hypertensive heart disease (HHD) underwent echocardiography, radionuclide ventriculography and the measurement of endothelial function before and after administration of candesartan (8mg/day). The subjects were divided into poorly controlled blood pressure (BP) (group P, n=6) and well controlled BP (group C, n=23). Endothelial function was evaluated from flow-dependent dilation, which was calculated as the percent change of the radial artery diameter during reactive hyperemia after upper arm occlusion, measured with a high-resolution ultrasound system. In group C, LV diastolic function and endothelial function were significantly (p<0.05) improved at 3 months after administration, LV systolic function and hypertrophy were significantly (p<0.05) improved after 6 months and these effects were maintained at 12 months. Even in group P, LV function, LV hypertrophy, endothelial function and brain natriuretic peptide were significantly (p<0.05) improved at 6 months after administration. In patients with HHD, candesartan improves LV systolic and diastolic function, LV hypertrophy and endothelial function within 6 months of administration, regardless of the control of BP.
- 社団法人日本循環器学会の論文
- 2002-10-20
著者
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内藤 滋人
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Isobe Naoki
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Adachi Hitoshi
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Toyama Takuji
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Taniguchi Koichi
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Kamiyama Hiroshi
Department of Cardiology, Isesaki-Sawa Medical Association Hospital
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Oshima Shigeru
Division of Cardiology, Gunma Prefectural Cardiovascular Center
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Ono Zenpei
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Naito Shigeto
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Hoshizaki Hiroshi
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Oshima Shigeru
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Ohshima Shigeru
Gunma Prefectural Cardiovascular Center
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Kamiyama Hiroshi
Depertment of Cardiology, Isesaki-Sawa Medical Association Hospital
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Kamiyama Hiroshi
Department Of Cardiology Isesaki-sawa Medical Association Hospital
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Taniguchi Koichi
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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