^<13>C呼気試験法による胃排出能検査の標準化(第2部論文集2-6)(<特集>^<13>C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)

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We investigated some important points to standardize ^<13>C breath test for gastric emptying. The ^<13>C0_2 infrared spectrophotometry analyzer for ^<13>C urea breath test to diagnose helicobacter pylori infection needed two breath samples which were collected before and after taking ^<13>C substance to measure Δ value. We used a few big sampling bags to collect breath samples before taking test meal. The Δ value between two breath samples collected without ^<13>C substance was very small. So there was no problem to regard separate breath samples as same ^<13>CO_2 concentration. Deep breathing and using big sampling bag did not influenced because total C02 concentration of breath sample was not influenced the Δ value when CO_2 concentration was more than 2%. Therefore the ^<13>C0_2 infrared spectrophotometry analyzer was useful to measure breath samples of ^<13>C breath test for gastric emptying. Previous studies usually used the half emptying time as a parameter to assume gastric emptying. Recently, the maximum ^<13>C excretion time was reported as a good parameter to assume gastric emptying. But in ^<13>C-octanoate breath test for solids test meal, the half emptying time and the maximum ^<13>C excretion time were considered parameters which were influenced by absorption, metabolism and excretion because there were strong correlations between the total cumulative ^<13>C recovery and these parameters. Reproducibility of the parameters in ^<13>C-acetate breath test for liquids were better than those in ^<13>C-octanoate breath test for solids. So we considered that ^<13>C-acetate breath test measured by the ^<13>CO_2 infrared spectrophotometry analyzer was a standard method of ^<13>C breath test for gastric emptying and that the maximum ^<13>C excretion time was more useful parameter than other parameters. To simplify ^<13>C breath test for gastric emptying, we considered to need more studies of normal subjects and patients.
日本平滑筋学会の論文
2002-12-27

^<13>C呼気試験法による胃排出能検査の標準化(第2部論文集2-6)(<特集>^<13>C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)

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