呼気試験法,ラジオアイソトープ法,アセトアミノフェン法による胃排出能検査の比較(第2部論文集2-3)(<特集>^<13>C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)

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概要

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• The ^<13>C-octanoic acid breath test has been thought to be one of the most important methods in gastric emptying, because it is non-invasive and needs no special device. In this study, we evaluated the gastric emptying results between the ^<13>C-octanoic acid breath tests, scintigraphy, and acetaminophen method. Ten patients with non-ulcer dyspepsia and 4 healthy volunteers were studied. For the test meal, we used scrambled egg, white bread, and 150 ml water and into the scrambled egg, 100 mg of ^<13>C-octanoic acid, 37 MBq 99mTc-DTPA, and 20 mg/kg body weight of acetaminophen were mixed. After eating, breath samples and scanning scintigraphic information was obtained up to 8 and 2 hours, respectively. Blood sample was obtained 45 minutes after eating and the concentration of serum acetaminophen were measured. Previously, a positive correlation between the half emptying time (t_<1/2>) determined by breath test and scintigraphy, was reported by Ghoos et al. (1993) (y=1.12x+66.1, R^2 = 0.79, p<0.0001) and in this study a positive correlation was found (y = 0.76x+113, R^2=0.29, p=0.047). There was a negative correlation between the t_<1/2> determined by scintigraphy and the concentration of serum acetaminophen (y=-0.12x+15.9, R^2=0.40, p=0.013). In case of that ^<13>CO_2 excretion of breath test was remained, even 8 hours after eating, t_<1/2> and lag phase determined by breath test were more delayed than actual state. In case of that ^<13>CO_2 excretion curve in early phase was drawn like sigmoid curve, t_<1/2> determined by breath test were more delayed than actual state. In case of that ^<13>CO_2 excretion curve had two peak-points, there was no problem. In conclusion the ^<13>C-octanoic acid breath test is a promising and reliable method for measuring gastric emptying.

• 日本平滑筋学会の論文
• 2002-12-27

著者

• 白坂 大輔

  神戸大学光学医療診療部

• 青山 伸郎

  神戸大学光学医療診療部

• 白坂 大輔

  神戸大学 医学部糖尿病消化器腎臓病学内科

• 白坂 大輔

  神戸大学 第2内科

• 加地 正明

  神戸大学 医学部糖尿病消化器腎臓病学内科

• 白坂 大輔

  神戸大学糖尿病代謝消化器腎臓病学内科

• 加地 正明

  神戸大学糖尿病代謝消化器腎臓病学内科

関連論文

• 第44回日本平滑筋学会ワークショップ「^C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて」ワークショップレポート(第1部ワークショップレポート)(^C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)
• 胃癌術前深達度診断に関する検討(食道・胃・十二指腸7, 第60回日本消化器外科学会総会)
• 呼気試験法,ラジオアイソトープ法,アセトアミノフェン法による胃排出能検査の比較(第2部論文集2-3)(^C呼気試験法胃排出能検査の現状と未来 : 標準化に向けて)
• これからどうなる薬物療法 H.pyloriの薬物療法:その適応と実際
• 十二指腸潰瘍とH.pylori (特集 胃炎・胃潰瘍・胃癌--H.Pyloriを中心として)

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