網膜循環動態並びに脳循環動態の臨床病態生理学的研究
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概要
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Object: The blood vessels of eye grounds is the only vessel, which can be seen directly under physio-logical conditions, and is considered important since it is the terminal blood vessel system from the inner carotid artery and a part of the blood vessels. The development of eye ground cameras makes possible the calculative observation of the reactivity of retinal blood vessels and contributes to the diagnosis of disorders of cerebral blood vessels. There have been many studies on cerebral circulation or metabolism. However are only a few reports on the comparison of the reactivity of retinal blood vessels and cerebral blood vessels in the same subjects and especially a complete report on the comparison of the reactivity of the blood vessels in the same patients with the same agents is not found. The author has attempted in this study to elucidate the significance of retinal blood vessels in the diagnosis of cerebral arteriosclerosis, by measuring retinal hemodynamics at a resting state and with vasoacting drugs and compared the results with the cerebral vascular reaction to the same agents in the same patients. Method and Materials: After mydriasis with noesynegyn, the eye ground was photographed by an eye ground camera and the diameters of retinal blood vessels were measured with the indirect method. The retinal central arterial pressure and brachial arterial pressure were measured and the retinal blood flow and the retinal vascular resistance before and after administration of various vasoacting drugs were calculated by the Mikuni's method which makes use of the Hagen Poiseuille rule. In some of the patients, the change of cerebral hemodynamics due to the same vasoacting agents were measured by cerebral vein catheter and the N_2O method to compare the reactions. In one hundred and eighty-two cases (age 17-76 years old, male 111, female 71) the retinal hemodynamics in a resting state were measured. In 116 of these cases, the reaction to various vasoacting drugs were observed. In addition, in 18 cases, the changes of cerebral hemodynamics were measured also.
- 社団法人日本循環器学会の論文
- 1973-02-20