The Effects of Coronary Vasodilators on Coronary and Systemic Circulation : Experiments on the Hearts of Anesthetized Dogs
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概要
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The effects of coronary vasodilators, papaverine, iproveratril, dipyridamole and carbochromene on myocardium and coronary vessels and their resultant effects on systemic circulation were studied. Coronary flow, aortic pressure, cardiac output and cardiac work were determined before and after intracoronary administration of the drugs in the anesthetized open chest dogs continuously using electromanometer and electromagnetic flowmeter. Each drug caused characteristic increase in coronary flow. Papaverine, iproveratril and carbochromene caused transient fall in aortic pressure. Iproveratril and carbochromene decreased and dipyridamole increased cardiac output significantly. Papaverine caused some decrease. Iproveratril decreased and dipyridamole increased cardiac work significantly. Papaverine and carbochromene caused some decrease.
- 社団法人日本循環器学会の論文
- 1970-09-20