興奮異常伝播時に於ける心房内特殊心筋系の機能に関する研究
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概要
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There have been many studies about the propagation of excitation of the heart, and the specific conduction systems of the ventricle has been both physiologically and histologically established. However there is no definite theory about the conduction system in the atrium. TAKAYASU and OOSAWA et al. observed electrophysiologically and histologically the existence of the specific conduction systems in the. atrium and reported that through these specific pathways the sinus impulse reached the A-V node. As a well known fact the cardiac pacemaker in physiologic condition originates from the sinus node, and the pacemaker when affected by physical, chemical or other factor may shift in the sinus node. Author basing on the existence of the atrial specific conduction systems as reported by TAKAYASU and OOSAWA et al. and using microelectrode method has studied the function of the so-called atrial specific pathway during pacemaker shift or atrio-ventricular conduction disturbance. Materials and Methods Eighty adult rabbits were used in this experiment. The right atrium of the excised heart was opened with the incision from the right atrioventricular groove to the lower portion of the sulcus terminalis without injuring the sinus node, A-V node and the OOSAWA's specific conduction systems. The preparation was fixed on the paraffin bed in the luicite chamber in which oxygenated Tyrode's solution was kept at a constant temperature level of 34℃. Two ultramicroelectrodes filled with 3Mol. KCl were employed, of which tips were less than 0.5μ in diameter. One was inserted into the sinus nodal region and the other was maintained in the portion of the A-V node. In this experiment, to cause the pacemaker shift or A-V conducting disturbance acetylcholine was dripped in the portion of the sinus node or in the perfusate. And then atrial specific conduction systems reported by TAKAYASU and OOSAWA were incised. To observe and record the action potentials from the nodes, a dual beam oscilloscope and a two-element penwriting electrocardiograph were used.
- 社団法人日本循環器学会の論文
- 1968-02-20