The Rate of Respiration and Incorporation of P^<32> into Adenosine Triphosohate of Rat Aorta Tissue

概要

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Tissue respiration and rate of incorporation of P^<32> into ATP of rat aorta were studied by using Warburg technique in vitro. 1. A decrease of the incorporation rate of P^<32> into ATP was observed within 45 minutes after sacrifice when the aortas were stored in a cold Krebs-Ringer-phosphate solution (pH 7 .4), 2. The metabolic inhibitors, cyanide and fluoride, depressed both the respiration and the incorporation of P^<32> into ATP. 3. The incorporation rate of P^<32> into ATP of aortas from 12 to 15 months old rats was lower than that of 1 to 2 months old rats, while no significant difference in Qo_2 of aortas from young and old rats was observed. 4. The enhancement of both the respiration and the incorporation of P^<32> into ATP of rat aorta by acetylcholine was significant in young but not in old rats. 5. The incorporation of P^<32> into ATP was depressed in aortas from rats fed a magnesium deficient diet for 2 to 4 weeks, while the oxygen uptake was not decreased in a significant amount.
社団法人日本循環器学会の論文
1965-01-20