EXPERIMENTAL STUDIES ON THE PULMONARY EDEMA INVESTIGATION WITH SPECIAL REFERENCE TO PERMEABILITY OF THE PULMONARY CAPILLARY FROM THE STANDPOINT OF PULMONARY LYMPHATIC RETURN
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概要
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The pulmonary lymphatic system originates from the portion around the alveolar duct and reaches the hilar area through the various lymphatic channel. The lymph flow in each lobe except the left upper lobe returns to the right jugular vein via the right thoracic duct, while the lymph flow from the left upper lobe usually returns to the left :jugular vein via the left thoracic duct. It should be reminded as a experimental condition that the some anastomoses occasionally exist between the both thoracic duct systems. In this experiment, however, the lymph flow from the right thoracic duct was regarded as the pulmonary lymph flow. The cases in which chile was mingled into the right thoracic duct and protein content exceeded over 5.0 g/dl were excluded from the materials studied. The pulmonary lymph flow from the right thoracic duct was normally minimal. By several authors, mean value of it was reported as 0.9 to 8.9 ml/hour in normal dogs. It seems that this variation is due to the individual and conditional difference In the experiments. The pulmonary lymph flow measured was within 0.16 to 1.55 ml/5 min with mean value of 0.55±0.23 ml/5 min in 23 cases of normal adult dogs. Thus, the pulmonary lymph flow is so little that it can't prevent happening of the acute pulmonary edema. It has been considered that the role of the pulmonary lymphatic system was to take up the protein molecule from the tissue space for making fall the colloid osmotic pressure and keeping the lung dry, rather than to drainage the edematous fluid. It was proved by results of experiment (1) and (2) that the pulmonary lymph flow was much affected by hemodynamic of the pulmonary circulation. Experiment (1) represented that the pulmonary capillary pressure was increased backwardly by the elevated left atrial pressure by obliterating the left atrium with balloon. This elevation of the pulmonary capillary wedge pressure caused the filtration rate of the fluid to increase through the capillary wall resulting in augumentation of intrapulmonary fluid volume followed by increment of the pulmonary lymph flow.
- 社団法人日本循環器学会の論文
- 1974-01-20
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関連論文
- EXPERIMENTAL STUDIES ON THE PULMONARY EDEMA INVESTIGATION WITH SPECIAL REFERENCE TO PERMEABILITY OF THE PULMONARY CAPILLARY FROM THE STANDPOINT OF PULMONARY LYMPHATIC RETURN
- Experimental Studies on Permeability of the Pulmonary Capillary