Studies on the Turnover of Myocardial Actomyosin in Dogs with Experimental Aortic Insufficiency and the Effect of Vitamin B_<12> on Actomyosin Metabolism

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概要

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• The turnover rate of actomyosin of myocardium and skeletal muscle was studied in control dogs and in those with experimentally produced aortic insufficiency. Based on the concept that vitamin B_<12> is an activating drug for myocardial metabolism, a large dose of it was given some of the dogs with aortic insufficiency to study the effect of vitamin B_<12> on the turnover of actomyosin in the overloaded heart. During the early period, when there was an acute increase in the load on the heart, the turnover rate of myocardial actomyosin in the dogs with aortic insufficiency increased and that of dogs administrated vitamin B_<12> increased remark-ably. However, during a relatively stable period (from 9th-30th day after production of aortic insufficiency), the turnover rate of myocardial actomyosin in both dogs with aortic insufficiency and those administrated vitamin B_12, approached control levels. From these observations it seems that increase in turnover rate is an important compensatory factor in the diastolic-overloaded heart and administration of vitamin B_12 is useful in treatment of the overloaded heart.

• 社団法人日本循環器学会の論文
• 1968-01-15

著者

• Yokota Yasushi

  The Third Dept. of Intern. Med., Kurume Univ. School of Med.

• Yokota Yasushi

  The Third Department Of Internal Medicine Kurume University School Of Medicine

関連論文

• EFFECTS OF DIETARY PROTEIN CONTENTS ON THE ULTRASTRUCTURE AND FUNCTION OF THE HEART IN THE SPONTANEOUSLY HYPERTENSIVE RATS. (SHR) WITH OR WITHOUT LOADING OF SODIUM CHLORIDE : IInd Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULA
• Studies on the Turnover of Myocardial Actomyosin in Dogs with Experimental Aortic Insufficiency and the Effect of Vitamin B_ on Actomyosin Metabolism

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