アナフィラキシーショック時の肝循環に関する研究 : 特に血中Catecholamine濃度との関連について

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Hypersensitive reaction to penicillin, or anaphylactic shock is a clinical problem of increasing magnitude. Although hepatic circulation in secondary shock due to trauma or hemorrhage has been extensively studied in animals especially on its irreversibility, hepatic circulation in anaphylactic shock has not yet been fully understood. In this paper, hepatic circulation in anaphylactic shock is discussed in correlation with systemic hemodynamics and the plasma concentration of catecholamines in dogs. The mechanism of the change of hepatic circulation is also mentioned. I HEPATIC CIRCULATION IN ANAPHY-LACTIC SHOCK Systemic and hepatic circulatory dynamics were examined simultaneously, for the furtherclarification of the possible relationship between those two systems. Material and Methods The observations reported in this paper were made on sensitized dogs under thiopentobarbital sodium anesthesia.(1) Adult dogs were sensitized by horse serum. At subsequent intervals after the last sensitization, anaphylaxis were provoked by a intravenous injection of horse serum.(2) Hepatic blood flow were determined by the modified Frank's method. A catheter was introduced from the right creasing magnitude. jugular vein into the hepatic vein and advanced as far as possible. Blood flow from the catheter, which is proved to be proportional to total hepatic flow, was measured directly and then the sampling blood was returned through the left jugular vein. Small amounts of heparin were used to prevent blood clotting in the catheter. (3) Cardiac output was determined by the method of STEWERT-HAMILTON using radio-iodinated serum albumin (RISA). RISA was rapidly introduced into the left ventricle or ascending aorta through a catheter advanced from the carotid artery. Counting of radio-activity changes in blood, which was sampled from the femoral artery, were made by using the Well type scintillation counter. (4) Mean artery pressure was measured by means of a strain gauge manometer connected with a tube in the femoral artery. Portal vein pressure was obtained by a catheter advanced into the vessel from a splenic branch vein and by attaching it to a water manometer. Inferior vena cava pressure was measured at the level of the vena caval ostia of the hepatic vein. (5) Total peripheral resistance was estimated by dividing mean artery pressure by cardiac out put. Splanchnic resistance was also calculated by the same principle.
社団法人日本循環器学会の論文
1965-05-20

アナフィラキシーショック時の肝循環に関する研究 : 特に血中Catecholamine濃度との関連について

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