アナフィラキシーショック時の循環動態 : 主として血圧および血漿蛋白の変動について
スポンサーリンク
概要
- 論文の詳細を見る
Purpose Recently there is an increasing incidence of penicillin shock. In this department a systematic research has been conducted for the last several years on the problem of the shock on the basis of a hypothesis that a shock due to penicillin must be something analogus to a serum anaphylactic shock encountered in animals. The problem assigned to this author in this systematic research was about the change in the blood circulation and plasma proteins during a serum anaphylactic shock in animals. Method s Materials used were about 50 dogs weighting 10-20kg. For the sensitization they were injected with horse serum in dose of 0.2 cc/kg subcutaneously on every other day, this injection alternating with the intravenous injection of horse serum in dose of 1.0cc/kg on every other day, and for the total period of 10 consecutive days. After the completion of the sensitization, 3 weeks were allowed, and, after this latent period, animals were thrown into anaphylactic shock by the rapid intravenous injection of the horse serum in dose of 2.5-5 cc/kg. The femoral arterial blood pressure was transmitted through a vinyl tubing to a mercury manometer and recorded on kymographion. Plasma proteins concentration was measured by a refracto- meter of Hitachi type and the protein fraction pattern was examined by the paper-electro-phoresis. Where the anti-shock agents were used, animals were treated as follows : in the chlorpromazine group, they were injected with chlorpromazine in dose of 2 mg/kg intramuscularly 40 minutes before the provocation of a shock ; in adrenalin group, animals were injected with adrenalin in dose of 2-3mg together with the physiological saline solution by the drip infusion after a shock has been provoked ; in the prednisone group this drug was injected intramuscularly in dose of 3mg/ kg in 3 divided doses, i.e., 24 hours, 8 hours, and immediately before the provocation of shock.
- 社団法人日本循環器学会の論文
- 1961-04-15
著者
関連論文
- 35) 不整脈に関する研究(第4報) : Phenothiazine誘導体の化学構造と抗不整脈作用について(第24回 日本循環器学会総会)
- アナフィラキシーショック時の循環動態 : 主として血圧および血漿蛋白の変動について