Renin-Angiotensin-A1dosterone系に関する研究 : 体液性調節および高血圧の成因に関する2,3の検討
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Right ventricular mechanical effects are usually measured as the mean value per minute. The author considers that the mechanical effect of the ejection time will estimate the right ventricular loading more exactly, because the right ventricular mechanical effect is performed mostly during the expulsion time. This paper was designed to study the change of right ventricular mechanical effects during the ejection time when pulmonary arterial pressure increases. METHODS The studies were performed by pulmonary catheterization, first under resting state and then under pulmonary pressure increase. 1) Estimation of ejection time was performed as that from the onset of the pulmonary arterial pressure curve to the pulmonary component of the second sound (p-II). 2) The mean pulmonary ejection pressure is calculated from the time integral of the pulmonary arterial pressure curve. 3) Right ventricular mechanical effects were estimated as mean values in one minute as usually and then as those during ejection time (α. β. γ). α. The right ventricular work in ejection time per minute (MWE) (CI × 1.055)(P^^-E_<pa> × 13.6)/1000 kgM/min/m^2 β.Ejection work per one stroke (SWE) MWE/HR kgM/min/m^2 γ. Ejection work per unit ejection time MWE/PII×HR ×10^4 gcm/sec10^<-1>/m^2 CI : cardiac index P^^-E_<pa> : mean pulmonary ejection pressure PII × HR : ejection time per minute 4) 10% oxygen and 7% carbon dioxide were loaded to increase the pulmonary arterial pressure. MATERIALS 1). A total of 31 cases which are 10 to 70 years old were studied. The ejection time was measured by venous catheterization and the mechanical effects were calculated while breathing room air. 2).In 12 of those cases the same investigations were repeated under inhalation of low oxygen or high carbon dioxide gas. RESULTS A. Between the ejection time per minute and the mean pressure of pulmonary artery in resting state a negative correlation was seen (r=-0.427). B. Effects of elevation of pulmonary arterial pressure upon the ejection time. When the pulmonary arterial pressure was raised by low oxygen or high carbon dioxide inhalation, the ejection time in one stoke shortened, but the ejection time per minute almost did not change owing to the increase of heart rate.
- 社団法人日本循環器学会の論文
- 1965-12-20
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