Serial Myocardial Lactate Metabolic Changes After Intracoronary Thrombolysis in Evolving Myocardial Infarction : SYMPOSIUM ON PATHOPHYSIOLOGY IN THE EARLY STAGE OF ACUTE MYOCARDIAL INFARCTION AND ITS TREATMENT : 51th Annual Scientific Session of the Japan

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To investigate whether early reperfusion (⩽3 hours) preserves aerobic myocardial metabolism in acute myocardial infarction, we examined serial changes in trans-cardiac lactate extraction after thrombolysis in 43 patients with acute antero-septal myocardial infarction. In the chronic phase, we also determined abnormally contracting segments as an index of infarct size and regional ejection fraction as an index of chronic regional cardiac function. In the early reperfuson group (⩽3 hours), positive lactate extraction was restored and there were small abnormally contracting segments and a high regional ejection fraction. The intermediate reperfusion group (3-5 hours), however, had sustained anaerobic lactate extraction, large abnormally contracting segments and a low regional ejection fraction. The late reperfusion (> 5 hours) group showed apparently aerobic lactate extraction, but had large abnormally contracting segments and a low regional ejection fraction. Thus, early reperfusion preserves aerobic lactate metabolism and good chronic ventricular function.
社団法人日本循環器学会の論文
1988-07-20