EXPERIMENTAL STUDIES ON ISCHEMIC INJURY AND REPERFUSION INJURY TO THE CARDIAC SARCOPLASMIC RETICULUM : The Myocardial Protective Effect of Nicorandil

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Ischemic and reperfusion injuries to the myocardium were evaluated by measuring cardiac function and the calcium binding capacity of the sarco-plasmic reticulum (SR) and by studying the myocardial protective effect of nicorandil. While undergoing cardiopulmonary bypass, dogs were subjected to 120-min global myocardial ischemia and then to 120-min reperfusion. Group I hearts were arrested with untreated potassium cardioplegic solution; Group II with the same solution containing 2 mg/L and Group III with the same plus 10 mg/L of nicorandil. Group III exhibited better recovery from ischemic and reperfusion injuries than Group I with recovery rates of LV dp/dt max (95.0 ± 28.9% vs 61.1 ± 30.4, p < 0.05) and LV negative dp/dt max (69.0 ± 12.5% vs 46.8 ± 21.7, p < 0.05). The 3 groups showed a marked decrease in the max calcium binding capacity during ischemia compared with the Control Group but exhibited no further decrease after reperfusion. After ischemia and reperfusion, Group III (30.4 ± 9.13 mol Ca/mg protein, 30.0 8.50) demonstrated a significantly higher binding capacity than Group I (17.0 2.41 and 18.3 1.01, p 0.05), while Group II did not. These results suggest that ischemia is more injurious to the calcium binding capacity of SR than reperfusion and that 10 mg/L of nicorandil added to the cardioplegic solution preserves SR function and enhances the recovery of cardiac function.
社団法人日本循環器学会の論文
1988-06-20