Influence of Bleeding and Acetylcholine on the Hepatic Circulation

概要

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Hemodynamics of the hepatic circulation in shock or marked hypotension due to bleeding and acetylcholine were studied using adult dogs. The portal flow and portal hepatic arterial flow ratio were measured with the electric conduction method using the salt solution as the indicatior. The arterial, portal venous and hepatic venous pressure were measured by catheterization. The experiments have shown that the hepatic circulatory change due to bleeding consists of two phases i.e. compensatory and incompensatory phase. In the former, hepatic flow decreases without any change of arterial blood pressure with the increases mesenteric capillary resistance. In the latter blood pressure decreases with the increases intrahepatic portal resistance with the resultant pooling of the blood in the portal region. The shock due to acetylcholine was shown to be hemodynamically similar to incompensatory phase of bleeding. Hemodynamic adjustment by the relative increase of hepatic arterial flow, compared with the portal, in shock or hypotension was also stressed.
社団法人日本循環器学会の論文
1969-04-20