ヒポキシアの冠循環におよぼす影響 : 心の酸素代謝を中心として

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Coronary sinus catheterization was performed on men with normal heart and those with coronary sclerosis, and on dogs with normal heart and those with coronary vascular lesions. Effects of hypoxia upon cardiac oxygen metabolism, especially on regulation of the coronary blood flow were studied. Results were as follows : 1) with regard to the rate of increase in coronary blood flow due to hypoxia, there was no statistical significance of differences between the group of normal men and that of coronary sclerosis. In dogs, however, the rate of increase was lower in dogs with coronary vascular lesions than in the normal dogs.2) In men, there was inverse correlation between the rate of decrease in arterial oxygen saturation and the rate of increase in coronary blood flow due to hypoxia.3) As for the rate of decrease in coronary sinus oxygen tension due to hypoxia, there was no statistical significance of differences between the two groups of men. In dogs, the rate of decrease was less in the group of coronary lesions than in the normal. The rate of decrease in arthrio-coronary venous difference due to hypoxia was less in the dogs with coronary lesions than in normal dogs, though in men there was no statistical significance between the two groups.4) In resting state there seemed to be an inverse correlation between the coronary blood flow and the arterio-coronary venous oxygen difference. The correlation became more apparent when hypoxic state was induced. In the coronary groups of both men and dogs, the increase in coronary blood flow was not so much as it should be expected from the decrease in the arterio-coronary venous oxygen difference.5) In men, there was good inverse correlation between coronary sinus oxygen tension and myocardial oxygen extraction coefficient in hypoxic state, as well as in resting state.6) In hypoxic state in men, release of potassium from myocardium was noted in 6 of 9 cases with coronary sclerosis. In 5 of these 6,there was an increase in myocardial oxygen extraction coefficient.On the contrary, myocardial oxygen extraction coefficient was decreased or not changed in those in which there was measurable myocardial uptake of potassium or no arterio-coronary venous potassium difference.
社団法人日本循環器学会の論文
1960-02-20

ヒポキシアの冠循環におよぼす影響 : 心の酸素代謝を中心として

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