低酵素呼吸による副腎分泌について : 皮質・髄質分泌同時観察による実験的研究

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The studies on the effect of induced hypoxemia to visceral circulation and metabolism in human beings have been carried out systematically in our department. The effect of hypoxemia to 17-OHCS secretion has been already reported by Ohta and to catecholamine secretion will be reported by Azuma, one of co-workers of author. The present study was designed to observe the effect of hypoxemia on adrenalcortex and adrenal medulla simultaneously, and to discuss the relationship between these two responses. The author also intended to add some knowledge concerning the effect of corticosteroid and catecholamine to the carbohydrate metabolism in hypoxic state. Materials and Methods Mongrel dogs of both sexes weighing 8 to 12kg, were cannulated in the lumbo-adrenal vein by modification of the method of Hume & Nelson. The experiments carried out 24 hours after operation under sodium pentobarbital anesthesia. Experiment 1 : Nine dogs were made to inhale 5 or 7% 0_2 in nitrogen gas from the Douglas bag through the tracheal cannula for 20 to 30 min-utes. Experiment 2: Six dogs were infused 10 or 20 u of ACTH diluted with saline intravenously for 10 minutes. To determine of adrenocortical hormone (17-OHCS) and catecholamine, adrenal venous blood samples were taken before and at each 10 or 20 minutes interval until 70 minutes after the treatment. At the same time the arterial blood samples were drawn from the femoral artery to determine the blood glucose level and arterial blood oxygen saturation. Results and Comments The results of this experiment are summarized as follows. 1. In hypoxic dogs, the secretion rate of the 17-OHCS & catecholamine showed such three patterns as (a) marked in crease of both secretion almost at the same time, (b) more rapid increase of the 17-OHCS secretion than that of catecholamine and (c) no increase of the catecholamine secretion at all in spite of a remarkable increase of the 17-OHCS. Generally, the secretion rate of the noradrenaline showed less than that of adrenaline. 2. Stimulation with ACTH 20 u showed no apparent increase of the catecholamine secretion, inspite of cortical hypersecretion, but in the dogs infused 20 u of ACTH rapid 17-OHCS response and late adrenaline increase were observed. 3. Data obtained from these two experiments suggested that the secretory response of adrenal cortex is more rapid and sensitive than that of adrenal medulla. 4. The change of the blood sugar level in hypoxic dogs did not relate to the increase of the 17-OHCS secretion, but paralleled the increase of the catecholamine, especially adrenaline secretion. By the fact that no apparent increase of the catecholamine secretion was observed in the dogs stimulated with 10 u of ACTH and a rapid and marked increase of the 17-OHCS secretion with a rather gradual increase of the adrenaline secretion whereas no increase of the noradrenaline secretion in 20 u of ACTH infused dogs, the adrenaline synthesis and secretion were suggested to be promoted not by the stimulation through the sympathetic nerve, but by the increase of the adrenocortical hormone secretion. Also from the experimental results in the low oxygen inhalated dogs, which were similar to those in the ACTH infused dogs in following findings as 1) more rapid and marked increase of the 17-OHCS secretion than that of the catecholamine and, 2) more significant secretory response of the adrenaline than that of the noradrenaline, the adrenal catecholamine secretion in hypoxemia was suggested to be activated not only by the stimulation through the sympathetic nerve, but also by the increased secretion of adrenocortical hormone.
社団法人日本循環器学会の論文
1972-06-20

低酵素呼吸による副腎分泌について : 皮質・髄質分泌同時観察による実験的研究

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