静脈うっ血の^<22>Naの血液-組織間交換に及ぼす影響 : 特に自律神経性関与について
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There are numerous studies on the blood-tissue exchange of easily diffusible solute and solvent molecules. Scarce, however, are the studies on the influence of elevated venous pressure on blood-tissue exchange of substances. Moreover, the participation of the autonomic nervous system in the alteration produced in blood-tissue exchange of easily-diffusible solutes by the elevation of venous pressure has been generally negated. Studies in cats and humans, by Mellander, showed that the elevation of venous pressure caused the capillary filtration coefficient (CFC) to decrease, and this was attributed primarily to the intrinsic contractile response of smooth muscles of minute blood vessels to stretch; the role of the autonomic nervous system in this reaction was considered to be of secondary importance. With measurments of the diffusion capacity (PS), a product of capillary permeability (P) and effective surface area of capillary vessels (S), Baker found that the elevation of venous pressure caused PS for ^<86>Rb in forelimbs of dogs to decrease by 13% with or without denervation, thus negating the contribution of the extrinsic nervous supply to this response. An earlier studies by Imao, of this labolatory, showed that the elevation of venous pressure in perfused hindlimbs of dogs caused PS for ^<22>Na to decrease by 30%. This paper will present a series of facts suggesting that the autonomic nervous system participates in the alteration produced in blood-tissue exchange of ^<22>Na by the elevation of venous pressure. Methods In adult mongorel dogs anesthetized with pentobarbital, hindlimbs on one side were examined for diffusion capacity (PS) for ^<22>Na with "indicator diffusion" method i.e., with a single intra-arterial injection, in a bolus, of a mixture of ^<22>NaCl and R^<131>ISA. Samples of blood flowing out of the cut-end of the corresponding femoral vein were examined for dilution curves of both ^<22>NaCl and R^<131>ISA and the extration ratio (E) for ^<22>Na was calculated from Chinard's formula, 1-E=Cv/C/Rv/R where C and R indicated concetration of ^<22>Na and R^<131>ISA in the injection fluids, and where suffix v specified the concentration in the femoral venous blood. From observed values of E, arid Q (rate of femoral venous blood flow), diffusion capacity (PS) for ^<22>Na was calculated from Renkin's equation, based on his single-capillary-model, PS=-Qln(1-E). Femoral venous blood flow (Q) was maintained constant by adjusting the arterial inflow. Local venous pressure was brought to the desired levels by adjusting the height of the outlet-orifice of a tube cannulated into the peripheral end of the cut femoral vein.
- 社団法人日本循環器学会の論文
- 1972-11-20
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