Studies on the Mechanism of Postalimentary Lipemia in Atherosclerosis
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概要
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Present studies have been undertaken to make observations on the possible correlation between heparin and LPL activity from the viewpoint of the mechanism for disposing ability of alimentary lipemia. In vitro study has revealed the fact that releasing of LPL from the rat's tissue was responsible to the biochemical action of heparin. Following the intraarterial or intravenous infusion of heparin, LPL seemed to be released rapidly, suggesting that LPL may be mobilized from the vascular wall or adjacent tissues. No difference of plasma LPL activity after heparin injection in the fasting state between young healthy persons and patients with atherosclerosis was found. Moreover no difference could be observed between the effect of heparin injection on the changes of plasma OD and LPL activities following fat intake in the controls and patients. An assumption was made that deficiency of apoenzyme could not be considered for the interpretation of disturbance in disposing ability of absorbed fat. Heparin-like substance in plasma was measured in the groups on fasting and postalimentary state. Plasma contents of heparin-like substance on fasting are found to be lower on the patients than the controls. One hour increase after fat intake failed to occur in the former, contrary to the latter, thus it is assumed that with the atherosclerotic patients the deficiency of heparin with disturbed releasing biochemical process are the responsible factor concerned. Further, the disturbed disposing ability of NEFA from blood stream is another factor to be considered in the abnormal metabolic process following fat absorption.
- 社団法人日本循環器学会の論文
- 1968-11-20