EFFECTS OF rHuEPO THERAPY ON EXERCISE CAPACITY IN HEMODIALYSIS PATIENTS WITH CORONARY ARTERY DISEASE

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概要

• 論文の詳細を見る

• We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9±0.7g/dl, (mean±S.D.) rose to 10.4±1.1 g/dl, (p<0.01) after three months of rHuEPO therapy. The partial correction of renal anemia resulted in a significant increase in exercise duration (from 278±84 sec to 384±74 sec, p<0.01) and maximum pressure-rate product (from 228.3±50.3mmHg・bpm/l0^2 to 262.8±40.4 mmHg・bpm/10^2, p<0.01). The maximum exercise-induced ST segment depression significantly decreased after treatment (from 1.3 ±0.5 mm to 0.5±0.5 mm, p<0.05). These results suggest that the improvement in maximum coronary oxygen supply exceeded the increased maximum myocardial oxygen requirements after the partial correction of renal anemia by rHuEPO therapy in hemodialysis patients with coronary artery disease.

• 社団法人日本循環器学会の論文
• 1993-05-20

著者

• Hase Hiroki

  Third Department of Internal Medicine, Toho University Ohashi Hospital

• Machii Kiyoshi

  Third Department of Internal Medicine, Toho University, Ohashi, Hospital

• Machii Kiyoshi

  The Third Department Of Internal Medicine Toho University School Of Medicine

• Machii Kiyoshi

  Third Department Of Internal Medicine Toho University Ohashi Hospital

• Hirai Hironori

  Department Of Cardiovascular Medicine Toho University Ohashi Medical Center

• MAGUCHI TETSUYA

  Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital

• Machii Kiyoshi

  Third Department Of Internal Medicine

• IMAMURA YOSHIHIKO

  Third Department of Internal Medicine, Toho University Ohashi Hospital

• NAKAMURA RYOICHI

  Third Department of Internal Medicine, Toho University Ohashi Hospital

• INISHI YOJI

  Third Department of Internal Medicine, Toho University Ohashi Hospital

• Hirai Hironori

  3rd. Department Of Internal Medicine Toho University School Of Medicine

• Inishi Yoji

  Third Department Of Internal Medicine Toho University Ohashi Hospital

• Hase Hiroki

  Third Department Of Internal Medicine Toho University Ohashi Hospital

• Nakamura Ryoichi

  Third Department Of Internal Medicine Toho University Ohashi Hospital

• Maguchi Tetsuya

  Third Department Of Internal Medicine Toho University Ohashi Hospital

• Imamura Yoshihiko

  Third Department Of Internal Medicine Toho University Ohashi Hospital

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