TIME COURSE OF RELEASED ATRIAL NATRIURETIC PEPTIDE AFTER ACUTE MYOCARDIAL INFARCTION

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The plasma concentration of atrial natriuretic peptide (pANP) was investigated at fixed times during 48h following the onset of an initial attack of mild acute myocardial infarction (AMI) in 11 patients. Six hours after onset, the mean pANP was elevated, but 6h later pANP had returned to the baseline level. Forty-eight hours after onset the mean pANP increased again. Thus, the curve of the time course of pANP consisted of 2 peaks separated by a dip. Six hours after onset, systemic hemodynamics and humoral factors were measured in 27 patients. At 48h they were measured in 14 patients. The late elevation of pANP correlated with mean pulmonary arterial wedge pressure (r=0.63, n=14, p<0.05), while the early elevation of pANP did not (r=0.31, n=27, n.s.). The early elevation of pANP correlated with plasma concentrations of both noradrenaline (r=0.55, n=27, p<0.01) and creatine phosphokinase (r=0.54, n=27, p<0.01). In addition, noradrenaline levels positively correlated with mean pulmonary arterial wedge pressure (r=0.38. n=27, p<0.05). The cause of the early elevation of pANP in AMI is unclear, but it is suggested that injury to myocardium and activated sympathetic nerve activity may be responsible in part.
社団法人日本循環器学会の論文
1991-12-20