Juxtaglomerular Apparatusに関する研究

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I. We recognized the gathering picture of five juxtaglomerular cells, in which endoplasmic reticulum was noted, on the investigation ofjuxtaglomerular apparatus by electronmicroscope. And we guessed the secretory function of these cells. On the following experiment we administered cortisone or AC TH to normal male albino rats, the increase of granules in the juxtaglomerular cell and juxtaglomerular index were noted 7 days after the administration while the decrease of these were noted 20 days after. From these observations, it was conceived that juxtaglomerular apparatus was effected humorally by hormone. II. If Kurotsu's b "sympathetrc zone" or c "parasympathetic zone" in the hypothalamus of normal male rabbits was lesioned or stimulated by electrode, the decrease of granules in the juxtaglomerular index on syrnpatic state and no alteration nor marked increase of that on parasympatic state were noted. On the experiment with adrenalin hydrochloride or pilocarpin hydrochloride, the glanules in the juxtaglomerular cell and juxtaglomerular index decreased with the former and the granules in the juxtaglomerular cell increased slightly with the latter. From these experiments, it was persumed that juxtaglomerular apparatus was effected by autonomic nerve, considerably by sympathetic nerve, and releases the substances for vasoconstrrctron
社団法人日本循環器学会の論文
1961-06-15