X線照射が心臓に及ぼす生物学的作用に関する研究 (第1報) : X線照射の心筋代謝に及ぼす影響
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Many opinions or theories have been expressed about whether or not the application of X-ray irradiation causes myocardial damage, but it has not yet cone to a conclusion. It has long been known that the X-ray irradiation gives heart muscle a histological change, but no literature which prescribed on metabolism under the X-ray irradiation has been found yet. When X-ray irradiation is applied to a living body, via autonomic nerve or acting as a stress, it may bring about some effect on the whole body in the end, and especially when the application of X-ray irradiation is limited to heart, it gives heart muscle various degenerations ; region near the epicardium, which is irradiated more directly, is influenced more severely, and the changes of the coronary vessel wall are more delayed. So it is supposed that X-ray irradiation will have a direct influence to the cells of the heart muscle. The experiments were performed to see how carbohydrate metabolism in the cells of heart muscle will be influenced when X-ray irradiation was applied. Experiment I. On the carbohydrate and creatine metabolism : 1) Coronary sinus catheterization was per-formed upon normal anaesthetized dogs. 4000r of X-ray (estimated dosis at the surface of the heart muscle) was applied to the heart. Before and 30 minutes, 1 hour and 2 hours after X-ray irradiation blood was sampled from the coronary vein and femoral artery, and the content of glucose, pyruvic and lactic acid and creative were measured. 2) Twenty minutes after 1000r X-ray irradiation (group I), or 40 minutes (group II), or two hours (group III) after 4000r X-ray irradiation on the rabbit, the animals were bled to death, and then differences between the heart muscle homogenates irradiated and not irradiated respectively, were compared. The respective heart muscle homogenates were divided into two; one was deproteinized with trichlor-acetic acid, and then glycogen, pyruvic and lactic acid of the filtrate were measured; the other was deproteinized with sulfuric acid and sodium tangstate, and then glucose, creative and creatinine of the filtrate were measured. 2. After destroying the brain and the spinal cord of the toad, thoracotomy was performed, the pericard was opened and 6925r of X-ray was applied to the heart. Twenty minutes later, a part of the heart muscle was resected and the lactic dehydrogenase activity was measured by Neiland method, recording the changes of the absorbance of 340mμ at 25℃.
- 社団法人日本循環器学会の論文
- 1961-03-15
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