Contraction and Relaxation of Vascular Smooth Muscle and Calcium, Strontium, Barium
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The effects of alterations in the extracellular Ca concentration and of lanthanum, verapamil and manganese were examined in the following four modes of contraction in vascular smooth muscle. Observation was also made on the relative effectiveness of Sr and Ba as substitutes for Ca in these contractions and in responses of relaxation by isoproterenol and papaverine. (1) .Spontaneous rhythmic contraction of rat portal vein was eliminated in Ca-O PSS and by lanthanum, verapamil and manganese. Sr could replace Ca with approximately the same effectiveness in generating phasic contraction but Ba produced only tonic contraction but not phasic contraction. (2) Spontaneous tonic contraction of resistance vessel from rat skeletal muscle disappeared when external Ca was removed and the Ca permeability blocking agents were added to perfusate. Sr and Ba could replace Ca. The order of effectiveness to maintain myogenic tone was Ba ≧ Ca > Sr. (3) Potassium-induced contraction of dog jugular vein was lost in Ca-O PSS and by lanthanum and verapamil. Sr and Ba were as effective as Ca in the substitution. (4) Norepinephrine-induced contraction of dog jugular vein remained partly in Ca-O PSS and after lanthanum and verapamil. However the residual response was greatly deteriorated. Sr and Ba was equally less effective than Ca. The importance of extracellular Ca, plasma membrane Ca and Ca entry into the cell in these modes of contraction was demonstrated. The diverse effectiveness of Sr and Ba in substitution of Ca may suggest different contractile mechanisms among the four modes of contraction. (5) Relaxation of isoproterenol was remarkably reduced or hardly observed in Ba or Sr PSS. A small amount of Ca restored relaxation in Ba and Sr solutions. (6) Relaxation by papaverine was demonstrated constantly and in the similar effectiveness among Ca, Ba and Sr solutions. This is an evidence for different mechanisms of relaxation between the two drugs. It is suggested that Ca is more effective in adrenergic drug and receptor interaction, whether contraction or relaxation than Ba and Sr.
- 社団法人日本循環器学会の論文
- 1975-06-20
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