MEASUREMENT OF MYOCARDIAL BLOOD FLOW BY MEANS OF EXTERNAL COUNTING METHOD USING 86-RUBIDIUM
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概要
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An attempt to measure myocardial blood flow (MBF) in a simple and atraumatic procedure has been made by means of an external counting method using a scintillation counter and a radioactive tracer 86-rubidium chloride. The method presented was based on the indicator fractionation principle proposed by Sapirstein. According to the principle, when a bolus of radioactive indicator 86-rubidium is injected intravenously, uptakes by various organs are proportional to their blood flow fraction of cardiac output. Experimental observations revealed that the relation had been maintained during initial five to ten minutes in human subjects. After a single injection of the tracer, external counting monitored precordially over the heart was made, obtaining radioactivity of first circulation of the tracer through heart as an equivalent of total injected dosis and radioactivity of later equilibration as an equivalent of fractional dosis uptaken by the heart. The myocardial blood flow (MBF) was calculated in the term of flow perfusing unit tissue mass, according to the equation presented, simultaneously obtaining the cardiac output and external cardiac work. Determination were made in thirty-six subjects. The mean value of MBF in ml/min 100 gm were 99 in twelve normal young subjects, 127 in two patients with hyperthroidism, 99 in ten aged subjects without ischemic heart disease (IHD) and 92 in twelve patients with IHD. In all of twenty-eight cases, the second determination were made following the administration of nitroglycerin or carbochromen. In nine young normal subjects without IHD the definite increase of MBF was observed, while in nine subjects with IHD, no increase of MBF was observed and tendency to decrease of the cardiac work was observed.
- 社団法人日本循環器学会の論文
- 1973-05-20
著者
関連論文
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- STUDY OF INTRARENAL DYNAMIC PROCESS BY SCINTILLATION CAMERA
- QUANTITATIVE ANALYSIS OF DILUTION CURVES OF CENTRAL CIRCULATORY SYSTEM SIMULTANEOUSLY RECORDED BY SCINTILLATION CAMERA
- MEASUREMENT OF MYOCARDIAL BLOOD FLOW BY MEANS OF EXTERNAL COUNTING METHOD USING 86-RUBIDIUM