各種高血圧ラットの毛細血管について
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概要
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Various type of experimental hypertensions (DCA hypertension, adrenal regeneration hypertension, renal hypertension and neurogenic hypertension) were produced in the Wistar rats, both female and male descendants were multiplied for each type of hypertension respectively. In these series of rats biological observations were made in the subungual capillary vessels of the hind legs, and width of arterial and venous loops, winding ratio, and number of windings in an arterial and a venous loop were measured to yield following results. 1) Morphologically speaking, subungual capillary vessels in rat legs are similar to those of human ungual capillary vessels and arterial loop are distinguishable from venous loops. 2) Capillary vessels in normal rats show seasonal change, dilated in summer and constricted in winter and contracted by noradrenaline administration. However, no changes are encountered under influences of room temperature. 3) All capillary vessels in various type of experimental hypertension rats incline to be narrowed and wound soon after hypertension being developed. The changes of capillaries are parallel to the degree of hypertension, at most in renal hypertension, next in neurogenic hypertension and about equal in DCA hyperor adrenal regeneration hypertension. 4) Capillary vessels in rats with renal hypertension influenced by administration of antihypertensive drug (Reserpin). Arterial and venous loops are dilated and winding ratios are decreased in association with falling blood pressure. If blood pressure goes up by stop giving reserpin, they are narrowed and wound. 5) Capillary vessels of experimental hypertensive descendant rats in successive generations are unchanged in series of F_1 from the normal group, but in after F_2 series narrowing of width and winding of loop are evident, the more late series the more severe changes are found. Degree of changes are great following the F_3 series which representative of spontaneous hypertension group. In F_5 series they show 2/3 in width of arterial loop, and 2〜4 times in winding ratio than the normal. Furthermore more capillary winding are seen after hypertension being persisted than before hypertension. 6) In conclusion, inner diameter of capillaries and winding ratio are closely related to the level of blood pressure, narrowing and winding of the capillaries play an important role to producing mechanism of hypertension.
- 社団法人日本循環器学会の論文
- 1964-05-20