EFFECTS OF FOUR ANTIARRHYTHMIC DRUGS ON THE INDUCTION AND TERMINATION OF PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA
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概要
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The electrophysiological effects of antiarrhythmic drugs were tested in 36 patients with recurrent paroxysmal supraventricular tachycardia (PSVT), 25 of whom had accessory pathway reentrant tachycardia (APRT) and 11 A-V nodal reentrant tachycardia (AVNRT ; 10 of the slow-fast type one of the fast-slow type). The test drugs were procainamide (used in 19 patients), verapamil (in 27), disopyramide (in 31), and propranolol (in 15). The drugs were tested for their ability to terminate episodes of PSVT as well as to inhibit their induction. Procainamide had an inhibitory effect on APRT in nine of 12^* patients (75%9 and terminated episodes of APRT in seven of 11^* patients (63.6%); in all of them V-A block was responsible for the termination. In four of six^* patients (66.7%) with slow-fast AVNRT and in one patient with fast-slow AVNRT, inhibition of the induction of tachycardia attacks was noted after procainamide. Termination of AVNRT was seen in the same number of patients. Verapamil inhibited the induction of APRT in 12 of 18^* patients (66.7%) and terminated episodes of APRT in 10 of 16^* patients (62.5%), all by A-V block. In six of eight^* patients (75%) with slow-fast AVNRT, inhibition of the induction as well as termination of tachycardia were noted after verapamil. Disopyramide had an inhibitory effect on APRT in seven of 23^* patients (30.4%) and terminated APRT in five of 21^* patients (23.8%) by V-A block, while AVNRT (all slow-fast type) was terminated in only one of eight^* patients (12.5%) by disopyramide. Disopyramide was less effective than previously reported. This could be attributed to a relatively low dosage and slow infusion speed. This could be attributed to a relatively low dosage and slow infusion speed. Propranolol inhibited the induction of APRT and terminated episodes of APRT in only one of 10^* patients (10%). In two of four^* patients (50%) with slow-fast AVNRT, an inhibitory effect by propranolol was noted, but termination was seen in only one patients.
- 社団法人日本循環器学会の論文
- 1986-10-20
著者
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Yoshlmura Shozo
Department Of Internal Medicine The Jikei University School Of Medicine
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YOSHIMURA Shozo
The Dept. Internal Med. Jikei Univ.School of Med
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KOMATSU CHIKAYOSHI
Komatsu Clinic
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YOSHIMURA Shozo
Jikei Univ.
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Yoshimura Shozo
Jikei University School Of Medicine The 4tjrl Department Of Internal Medicine Tokyo Japan
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Komatsu Chikayoshi
The 4th Department of Internal Medicine Jikei University School of Medicine
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Tokuhisa Yasutaka
The 4th Department of Internal Medicine Jikei University School of Medicine
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Tateishi Osamu
The 4th Department Of Internal Medicine Jikei University School Of Medicine
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Tateishi Osamu
Department Of Internal Medicine (iv) The Jikei University School Of Medicine
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Yasutaka Tokuhisa
The 4th Department Of Internal Medicine Jikei University School Of Medicine
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Ishlnaga Takanari
The 4th Department Of Internal Medicine Jikei University School Of Medicine
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Yoshimura Shozo
Department Of Internal Medicine The Jikei University School Of Medicine
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KOMATSU Chikayoshi
Department of Internal Medicine, The Jikei University School of Medicine
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ISHINAGA Takanari
Department of Internal Medicine, The Jikei University School of Medicine
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TOKUHISA Yasutaka
Department of Internal Medicine, The Jikei University School of Medicine
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Yoshimura Shozo
The 1st Dept. Of Int. Med. The Jikei Univ. School Of Med.
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Ishinaca Takanari
The 4th Department Of Internal Medicine Jikei University School Of Medicine
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YOSHIMURA Shozo
Department of Central Clinical Laboratory, Toho University School of Medicine
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