Genetic Study of Essential Hypertension : III. Essential Hypertension : SYMPOSIUM ON GENE-ENVIRONMENT INTERACTION IN CARDIOVASCULAR DISEASES

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概要

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• The authors carried out blood pressure investigations in different parts and over long periods to make an analysis of the inheritance of essential hypertension from various aspects. The results obtained, including many already reported by the authors as wel as those reported by other investigators and analyzed by the authors, may be systematically summarized as follows: 1) Essential hypertension is a polygenic disease governed by polygenic systems. 2) The heritability of the disease is estimated at about 50%, indicating that inheritance and environment are of equal importance as factors for its appearance. 3) The number of gene loci (N), the effect of a gene (α), and the frequency of a positive gene (q) were estimated at N=13 to 15, α=4 to 8, and q=0.50, respectively. 4) The correlation between the variation of blood pressure distribution with an increase in age and the action of polygenes was analysed genetically by setting up models, with the result suggesting the variation in the variance of gene effect to be strongly influenced by an increase in age. 5) Juvenile and non-juvenile hypertension were analyzed for their genetic correlation to suggest that they may be governed not by different gene groups, but by pleiotropism at least. 6) A method has been devised by which the reciprocal action between the genotype and environment responsible for essential hypertension can be estimated from data for monozygotic twins, and by this method the reciprocal action between genotype and environment was estimated to give a piece of information of importance. We are afraid that some of the foregoing estimates may not necessarily be representative of the general population tested because of the limited number of cases examined. Further investigations under a longterm program for estimates of higher accuracy are believed to contribute much to clinical genetics.

• 社団法人日本循環器学会の論文
• 1978-11-20

著者

• Miyao Sadanobu

  Professor Emeritus Kumamoto University

• Furusho Toshiyuki

  Department Of Hygiene School Of Medicine. Kagoshima University

関連論文

• THE MANIFESTATION OF GENOTYPES RESPONSIBLE FOR BLOOD PRESSURE AND BLOOD SUGAR LEVEL
• Genetic Study of Essential Hypertension : III. Essential Hypertension : SYMPOSIUM ON GENE-ENVIRONMENT INTERACTION IN CARDIOVASCULAR DISEASES

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