EFFECTS OF HIGH FREQUENCY STIMULATION ON THE MEMBRANE POTENTIAL OF ISOLATED VENTRICULAR MUSCLE AND PURKINJE FIBERS
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概要
- 論文の詳細を見る
Effects of high frequency (HF) stimulation on membrane potential were examined in ventricular muscle and Purkinje fibers, which were isolated from canine and rabbit hearts, by using microelectrode techniques. When the stimulating frequency of preparations was increased abruptly from basic frequency (BF, 0-30/min) to high frequency (HF, 60-150/min), the maximum diastolic potential (MDP) of both ventricular muscle and Purkinje fibers decreased with each beat and reached a minimal value (initial depolarization). Then, MDP gradually increased beyond the steady state level at BF (hyperpolarization). On returning the stimulating frequency from HF to BF, a further terminal hyperpolarization ensued, and finally MDP decayed back to the control level within several minutes. The intensity of MDP change (both depolarization and hyperpolarization) was apparently greater in ventricular muscle than in Purkinje fibers. A significant increase of threshold current for excitation and a slight increase of membrane input resistance were also observed at the hyperpolarized period after HF stimulation. Lowering the temperature of the perfusate from 37℃ (control) to 31℃ or 26℃ led to an augmentation of initial depolarization and also a decrease in the intensity of ensuing hyperpolarization. The decay time of the hyperpolarization after HF stimulation was much prolonged. In the presence of ouabain, HF stimulation caused a monotonic decline in MDP and no hyperpolarization was recorded during and after HF stimulation. These results suggest that an active ion transport through the sodium pump contributes significantly to the electrical properties of ventricular muscle as well as the Purkinje fibers when the firing rate of the fibers is abruptly changed.
- 社団法人日本循環器学会の論文
- 1981-04-20
著者
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Toyama Junji
名古屋大学 大学院医学系研究科循環器内科
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Toyama Junji
Department Of Circulation Division Of Regulation Of Organ Function Research Institute Of Environment
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Kodama Itsuo
Department Of Cardiovascular Research R.i.e.m. Nagoya University
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Toyama Junji
Department Of Cardiology Aichi Prefectural Owari Hospital Cardiovascular Center
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Yamada Kazuo
Department Of Architecture Faculty Of Engineering Aichi Institute Of Technoligy
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