CLINICAL STUDY OF THE HAEMODYNAMIC EFFECT OF A BETAADRENERGIC RECEPTOR BLOCKER ACEBUTOLOL IN ANAESTHESIA
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概要
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The clinical evaluation of β-adrenergic receptor blocker acebutolol in anaesthesia was done and following results were obtained. 1) Acebutolol resembles practolol in potency but has a more modest degree of cardioselectivity. 2) Antiarrhythmic action is excellent. A seventy-three percent cure ratio was obtained with the first dose of 3 7.4μg.kg^<-1>. This dose is the second largest dose to the dose of practolol among 10 β-adrenergic receptor blockers which were studied by the authors in order to obtain the same effect. The maximum dose required reached 250μg.kg^<-1> in one case. The final cure ratio of arrhythmia was 96%. Preventive effects on epinephrine-induced arrhythmia are sufficient. 3) Antitachycardiac action is moderate. The cure ratio of tachycardia from the first dose of 37.2μg.kg^<-1> was 88%. The maximum dose required reached 80 μg.kg^<-1> in one case. The heart rate in all cases was successfully reduced by 18.6%. The effect of the drug appears fast and therefore can be effective in treating tachycardia during anaesthesia. 4) Systolic, diastolic, and mean arterial pressure decreased moderately. Pulse pressure decreased considerably. Decrease of stroke volume was a minimum, but cardiac output decreased 20%. Decrease of cardiac work and Katz's index indicate reduced myocardial oxygen consumption. Total peripheral resistance increased. 5) Cardiovascular depression by 37.3μg.kg^<-1> of acebutolol is milder than those of 45μg.kg^<-1> of practolol which is considered as equipotent. When a dose less than 40 μg.kg^<-1> of acebutolol is administered, cardiovascular depression is not serious in a severely damaged myocardial case. 6) No complication was noted in asthmatic or emphysematous patients when acebutolol is used in a small fractional dose. Twenty μg.kg^<-1> will be safe. The authors' study suggests that acebutolol has a cardiovascular selectivity, and is effective as an antiarrhythmic and antitachycardiac agent in a patient under anaesthesia with safety.
- 社団法人日本循環器学会の論文
- 1980-05-20
著者
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Miyazaki Masao
Department Of Agro-bioscience Faculty Of Agriculture Iwate University
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Miyazaki Masao
Department Of Anaesthesia Kyoto Prefectural University Of Medicine
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Yokono Satoshi
Department Of Anaesthesia Kyoto Prefectural University Of Medicine
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