EFFECTS OF PROSTAGLANDIN E_1 AND ISOSORBIDE DINITRATE ON ACUTE HYPOZIC PULMONARY VASOCONSTRICTION IN CONSCIOUS SHEEP
スポンサーリンク
概要
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The pulmonary vascular effects of prostaglandin E_1 (PGE_1) and isosorbide dinitrate (ISD) on acute hypoxic pulmonary vasoconstriction in conscious sheep were studied. While the animals inhaled room air or hypoxic gas (O_2:N_2 =1.9), PGE_1 (0.5μg/kg/min) and ISD (10μg/kg/min) were administered intravenously for 20 min, using an infusion pump. The changes of pulmonary arterial pressure (P^^-_<PA>) or pulmonary vascular resistance (PVR) in room air due to PGE_1 decreased P^^-_<PA> by 14.7% (p<0.05) and PVR by 14.5% (p<0.05). The effect of PGE_1 in room air on systemic arterial pressure (P^^-_<SA>) remained nearly constant, whereas slight decreases in systemic vascular resistance (SVR) were noticed. In hypoxic condition, P^^-_<SA> levels were slightly decreased by PGE_1, but SVR indicated a slight degree of delayed rise. When ISD in room air was administered, the values of P^^-_<PA>, PVR, P^^-_<SA> and SVR decreased by 9% (p<0.05), 10.4% (p<0.05), 17.7% (p<0.05) and 21.8% (p<0.05), respectively. In hypoxic condition, ISD decreased the values of P^^-_<PA>, PVR, P^^-_<SA> and SVR by 14.7% (p<0.05), 15.8% (p<0.05), 10.2% (p<0.05) and 6.7% (p<0.05), respectively. In summary in hypoxic condition both PGE_1 and ISD cause similar decreases of P^^-_<PA> and PVR. Furthermore, there was a very little decrease in P^^-_<SA> during PGE_1 infusion in the hypoxic condition. These findings may suggest that the vasodilator actions of PGE_1 were not evident in the pulmonary vascular bed under resting conditions, but could be demonstrated in vessels with increased tone produced by hypoxia without a marked fall in the systemic arterial pressure.
- 社団法人日本循環器学会の論文
- 1985-10-20
著者
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Yoshimura K
Shinshu Univ. Matsumoto Jpn
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YOSHIMURA KAZUHIKO
An outline of this work was presented at the 46th Annual Meeting of the Japanese Circulation Society