Vasodilator Therapy for Right Ventricular Failure : SYMPOSIUM ON HEART FAILURE AND VASODILATOR THERAPY
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概要
- 論文の詳細を見る
The effects of PGE_1 and ISD on right ventricular performance in patients with pulmonary hypertension secondary to chronic lung disease were evaluated, and the following results were obtained. I) Effects of PGE_1 on Right Ventricular Failure The effects of PGE_1 (intravenous infusion, 0.01 to 0.03 μg/kg/min) on right ventricular failure were studied in 12 patients with acute exacerbation of chronic respiratory failure. PGE_1 resulted in a significant fall in RAP (p<0.05), PAMP (from 33.8±7.6 to 29.3±5.7 mmHg, p<0.005) and TPVR (p<0.001), whereas a significant increase in CI (from 3.4±0.6 to 3.9±0.61/min/m^2), p<0.001) and SI (p<0.005). PaO_2 was significantly decreased by PGE_1 (p<0.02), however p_v^^-O_2 remained unchanged because of a significant increase of O_2-transport (p<0.01). PGE_1 induced active vasodilation of the pulmonary vascular beds and reduced a right ventricular afterload. We concluded that PGE_1 improved the right ventricular failure secondary to chronic lung disease. II) Effects of ISD on Right Ventricular Performance The effects of ISD (intravenous infusion, 0.05 mg/kg/hr) on right ventricular performance were studied at rest and during exercise in 11 patients with clinically stable chronic respiratory failure. At rest and during exercise, ISD induced a significant decrease in RAP, PAMP and CI, however no change in TPVR. RVWI was reduced significantly by ISD (from 2.5±0.8 to 1.9±0.5 kg・m/min/m^2, p<0.01) during exercise. ISD reduced the right ventricular preload by means of venodilation, and reduced right ventricular work. We concluded that ISD improved the right ventricular performance of cor pulmonale.
- 社団法人日本循環器学会の論文
- 1984-04-20
著者
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Sawada Masateru
The Third Department Of Internal Medicine Osaka Prefectural Habikino Hospital
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Tanaka Nobuyuki
The Third Department Of Internal Medicine Osaka Prefectural Habikino Hospital
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Araki Yoshihiko
The Third Department Of Internal Medicine Osaka Prefectural Habikino Hospital
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Fujita Kazushige
The Third Department Of Internal Medicine Osaka Prefectural Habikino Hospital
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SAKAGUCHI KAZUSHIGE
The Third Department of Internal Medicine Osaka Prefectural Habikino Hospital
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