Captopril Reduced Plasminogen Activater Inhibiter Activity in Patients With Acute Myocardial Infarction
スポンサーリンク
概要
- 論文の詳細を見る
Recent clinical trials have demonstrated that the administration of angiotensin-converting enzyme (ACE) inhibitors to patients with myocardial infarction reduces the incidence of recurrent myocardial infarction. It has also been reported that an elevated level of plasminogen activator inhibitor (PAI) appears to constitute a marker of the risk of recurrent coronary thrombosis. To determine whether the ACE inhibitor captopril reduces plasma PAI inhibitor activity, we measured changes in plasma PAI activity (IU/ml), tissue plasminogen activator (t-PA) antigen (ng/ml), and serum ACE activity (IU/L) in 14 survivors of myocardial infarction receiving captopril therapy (37.5 mg daily) and compared them with the values in 15 placebo-treated patients chosen at random. Blood sampling was performed at 07.00 h. In the captopril-treated group, serum ACE activity decreased significantly, from 14.0±0.8 to 11.5±1.2I U/L 24h after captopril therapy (p<0.01), and those of PAI activity and t-PA antigen also decreased significantly-from 11.9±2.8 to 5.5±2.2 IU/ml (p<0.02) and from 9.9±1.0 to 7.5±0.9 ng/ml (p<0.05), respectively 48 h after captopril therapy. However, the levels of ACE activity, PAI activity, and t-PA antigen remained unchanged during the study period in the placebo group. Thus, our data indicate that the administration of captopril to patients with acute myocardial infarction may result in a reduced frequency of recurrent coronary thrombosis by increasing fibrinolytic capacity.
- 社団法人日本循環器学会の論文
- 1997-03-20
著者
-
Ogawa Hisao
Kumamoto University Hospital
-
Yasue Hirofumi
Kumamoto Kinoh Hospital, Kumamoto Aging Research Institute
-
Sumida Hitoshi
Kumamoto AMI Study Group
-
Sakamoto Tomohiro
Kumamoto AMI Study Group, Kumamoto Prefecture
-
Yasue H
Kumamoto Univ. School Of Medicine
-
Ogawa Hisao
Kumamoto University
-
Kataoka Keiichiro
Kumamoto Ami Study Group
-
ARAI Hidekazu
Division of Cardiology, Fukuoka Tokusyukai Hospital
-
Takazoe Keiji
Division of Cardiology, Kumamoto University School of Medicine
-
Moriyama Yasushi
Division of Cardiology, Fukuoka Tokusyukai Hospital
-
Oshima Shuich
Division of Cardiology, Fukuoka Tokusyukai Hospital
-
Honda Yoshio
Division of Cardiology, Fukuoka Tokusyukai Hospital
-
Hirashima Osamu
Division of Cardiology, Fukuoka Tokusyukai Hospital
-
Suefuji Hisakazu
Kumamoto University School of Medicine
-
Kaikita Koichi
Kumamoto University School of Medicine
-
Oshima Shuichi
Kumamoto Central Hospital
-
Yasue Hirofumi
Division Of Cardiology Kumamoto University Medical School
-
Arai Hidekazu
Division Of Cardiology Fukuoka Tokusyukai Hospital
-
Matsuzawa Yuji
山口大学 医学系研究科器官病態内科学
-
Yasue Hirofumi
Kumamoto Aging Resaarch Institute Kumamoto Japan
-
Takazoe Keiji
Division Of Cardiology Kumamoto Central Hospital
-
Oshima Shuich
Division Of Cardiology Kumamoto Central Hospital
-
Honda Yoshio
Division Of Cardiology Fukuoka Tokusyukai Hospital
-
Moriyama Yasushi
Division Of Cardiology Kumamoto Central Hospital
-
Suefuji Hisakazu
Division Of Cardovascular Center Kumamoto National Hospital
-
Yasue Hirofumi
Division Of Cardiology School Of Medicine Kumamoto University
-
Arai Hidekazu
Department Of Cardiology Fukuoka Osumi-kanoya Hospital
-
Hirashima Osamu
Department Of Internal Medicine Japanese Red Cross Kumamoto Hospital
-
Sakamoto Tomohito
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
-
Oshima Shuichi
Division Of Cardiology Kumamoto Central Hospital
-
Yasue Hirofumi
Department Of Cardiology Kumamoto City Hospital
-
Honda Osamu
Department Of Cardiovascular Medicine Kumamoto University School Of Medicine
-
Morikami Yasuhiro
Division Of Cardiology Kumamoto City Hospital
-
Yasue Hirofumi
Division Of Cardiovascular Medicine Kumamoto Kinoh Hospital Kumamoto Aging Research Institute
-
Honda Osamu
Department Of Internal Medicine Japanese Red Cross Kumamoto Hospital
-
Tanoue Kichi
Division Of Cardiology Kumamoto Central Hospital
-
Kaikita Koichi
Kumamoto Ami Study Group
-
Yoshida Masahiro
The Department Of Atherosclerosis And Diabetes National Cardiovascular Center
-
Ooshima Shuuichi
Division Of Cardiology Kumamoto Central Hospital
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