Long term study of diabetic nephropathy : Effect of Korean red ginseng(Clinical study)

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The prognosis of diabetic nephropathy is likely to be poor, so it is important to inhibit the progression of nephropathy and to postpone or avoid the initiation of hemodialysis (HD). We retrospectively investigated the effect of Korean red ginseng on nephropathy using the urinary albumin/creatinine ratio (A/C ratio) as an index. A total of 165 outpatients with type 2 diabetes attending our diabetes clinic were divided into a group treated with Korean red ginseng ("Seikan-syo": n=106) and a group without ginseng (n=59). Patients were also stratified into classes A, B, C, and D based on the A/C ratio (<30, 31-100, 101-300, and >301 mglg・creatinine, respectively). All patients were followed up for 10 years between 1986 and 1995. There were significantly more patients who remained in class A after 10 years in the ginseng group than in the control group (P<10^<-19>), and fewer patients progressed to classes C or D in the former group. Initiation of HD or death were only observed after patients entered class D. These findings suggest that it is important to prevent progression to class D. We confirmed that the preferable time to initiate treatment with red ginseng is when patients are in class A or B based on the A/C ratio. Because only a few patients started HD even when they were in classes C or D, use of red ginseng may have broader indications. We also confirmed by this 10-year follow-up study that the cut-off point for treatment of nephropathy with red ginseng should be class B with an A/C ratio <100 mg/g・creatinine. Measurement of the A/C ratio over time seems to provide a useful index for assessing the progression of nephropathy. Red ginseng inhibited the progression of nephropathy, but additional management to control the blood glucose level and blood pressure is also essential.
和漢医薬学会の論文

Long term study of diabetic nephropathy : Effect of Korean red ginseng(Clinical study)

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