水中に置かれた生体の走査型プローブ顕微鏡を用いた粘弾性評価法

概要

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An analytical method is proposed to evaluate the viscoelasticity of a biomaterial in water by the scanning probe microscope. The proposed method utilizes the dependence of amplitude and phase lag of cantilever vibration on the viscoelasticity when the tip on the cantilever cyclically penetrates into the cell. The cyclical penetrations are carried out in two ways; one is by excitation of the cantilever fixed end, and other by that of the table. The analysis takes the drag force of water due to the cantilever vibration into account. The stiffness and the viscosity of the cell are analytically related with the amplitude and the phase lag of the cantilever vibration. The results shows that the relations among the amplitude, the phase lag, stiffness and viscosity vary significantly depending on the excitation frequencies of the cantilever fixed end and the table.
社団法人日本機械学会の論文
2001-11-25