ポリアミン修飾ポリビニルアルコール中空糸膜のエンドトキシン吸着除去能の検討と応用

概要

論文の詳細を見る
Microporous PVA hollow-fiber membranes (pore size, 0.2μm) were modified by immoblizing covalently various cationic amino ligands onto membranes , and their endotoxin (ET) ad sorptive capacity in aqueous solutions were examined. As a result, polyallylamine (PAA, Mw 15,000) modified membranes were found to display the highest ET adsorption (removal efficiency of above 95%) due to strong electrostatic interaction. With use of PAA as a base amine polymer, effects of hydrophobic, long-chain alkyl groups as well as secondary and tertiary amine groups on ET adsorption were investgated by introducing these ligand groups to PAA-modified membranes. It was demonstrated that the N-substituted PAA-modified membranes containing both cationic amines and hydrophobic substituents such as lauryl groups exhibited considerably high ET adsorption, while a hydrophobic ligand itself showed relatively low ET adsorption with removal efficiency of 74%. Among three kinds of amine groups, the primary amine group was found the most effective for ET adsorption. In a filtration test with mini-filter modules, excellent ET removal of above 99% has been achieved. It is suggested that PAA-or N-substisuted PAA-modified membranes would be applicable as ET removal filters for preparation of highly purfied dialysis fluids in hemodialysis units.
日本医療機器学会の論文
2005-02-01