ツベルクリン過敏性の受身伝達機構に関する研究

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Passive transfer of tuberculin hypersensitivity was studied by using a diffusion chamber, through which proteins were permeable but a cell was not. Peritoneal cells of guinea pigs which were sensitized with heatkilled tubercle bacilli suspended in liquid paraffin were enclosed in a diffusion chamber and inserted in peritoneal cavities of normal recipient guinea pigs. The tuberculin skin reaction of the recipient animals turned to positive, when the number of cells were the order of 10^8 or more. Furthermore, the increase of an oxgen consumption, the cytolysis and the tuberculin neutralizing activity of the peritoneal cells of passively sensitized recipient animals were recognized by adding tuberculin in the cell suspension. These phenomena, however, were not recognized in liver, spleen, lymph node and peripheral white blood cells of these passively sensitized animals. It was also recognized that the tuberculin hypersensitivity was transfered from the sensitized cells to the peritoneal cells, the spleen cells, and the lymphocytes of non-sensitized guinea pigs, when the non-sensitized cells were incubated and shaked in vitro with the diffusion chamber in which the sensitized cells were enclosed. From the results mentioned above, it is concluded that the tuberculin hypersensitivity can be transfered to the peritoneal cells of the recipient by the sensitized cells through the membrance of a diffusion chamber, and that the cells of recipient themselve take a part in the tuberculin skin reaction of the recipient animals.
日本アレルギー学会の論文
1968-05-30

ツベルクリン過敏性の受身伝達機構に関する研究

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