食餌アレルギーの研究 : 第3報 小児ストロフルスにおける食餌アレルゲンと血清 BDB 抗体価との関係

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概要

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• Sixteen patients, from 9 months to 4 years old, with papular urticaria, were investigated clinically and serologically from view point of food allergy. Firstly, food allergen responsible for the disease was suspected from food diary and history of the patient. Secondly, elimination and provocation test on the suspected food allergens were carried out. Thirdly, antibodies in patients' sera to hen's egg and cow's milk were determined by Bis-diazotized benzidine hemagglutnation test (BDB test). 1) In all sisteen cases improvement of the symptom was observed after elimination of the food allergen that is the appearance of new eruption was prevented almost completely after twenty-four hours and the symptoms were disappeared thereafter. 2) Following ingestion of the food allergen the symptoms began to appear within twenty-four hours in most cases. Erythema or Urticaria accompanied by itching was induced within twenty-four hours and followed by solid papule thereafter. By further administration of food allergen, the papule developed to vesicle and increased in number. 3) Fourteen cases showed other allergic manifestations than papular urticaria in their history or as present complication. These manifestations were consisted of eczema, urticaria, mucocutaneo-ocular syndrome, diarrhea, vomiting, wheezing, nasal and ocular discharge. Their course ran almost parallel with papular urticaria by elimination or administration of the food allergen. 4) The allergen responsible for the disease were determined to be hen's egg in 8 cases, cow's milk in 5 cases and the both in 3 cases. 5) BDB test of the patients' sera showed in all the cases of hen's egg allergy markedly high titers, ranging from 1:1, 280 to 1:5, 120, to either egg white or egg yolk, while on the other hand, in all the cases of cow's milk allergy similar high titers, ranging from 1:640 to 1:2, 560 to only lactoalbumin and not so high titers to lacto-globulin or casein. In 2 cases with both allergy, rather high titers were observed to lactoalbumin, ranging from 1:320 to 1:2, 560 and to egg yolk, ranging from 1:160 to 1:2, 560. Conclusion: From the results it became clear that papular urticaria was caused etiologically by food allergy, mainly to hen's egg or cow's milk, and that BDB hemagglutinaion test was helpful in detecting food allergen responsible for this disease.

• 1966-03-30

著者

• 鈴木 政子

  群馬大学医学部小児科学教室

関連論文

• 食餌アレルギーの研究 : 第4報 乳児アレルギー性下痢症における牛乳アレルゲンとそのBDB抗体価との関係
• 食餌アレルギーの研究 : 第3報 小児ストロフルスにおける食餌アレルゲンと血清 BDB 抗体価との関係
• 28. 二, 三小児疾患における抗血管抗体の証明(第10回日本アレルギー学会総会一般演題)
• 46.食餌アレルギーに関する研究 : 第3報 食餌抗原の母乳への移行について(第13回日本アレルギー学会総会)

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