気管支喘息患者における室内塵抗原液皮内反応陽性限界濃度 (閾値)の研究およびPrausnitz-Kustner 反応の検討

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Several studies were carried out concerning threshold of tuberculin reaction. Recently attention has been paid to the threshold of immediate type of skin reaction (end point of antigen dilution) and its clinical significance. In this paper following points were studied and discussed: cause of individual difference in the threshold of skin test, advantage of the use of threshold dilution as a method of skin test in asthmatic patients, and change of the threshold values following hyposensitization. As concerned flare of the immediate skin reaction, either reaction by standard antigen dilution or threshold measurement showed skin sensitivity to antigen. There was no difference in skin sensitivity to histamin between in house dust-positive subjects and house dust-negative ones, and there was no significant correlation between sensitivity (threshold values) to histamin and that to house dust in asthmatic patients. Prausnitz-Kustner titers proved to be variable even with the serum from a single patient. It was concluded statisically that comparison of Prausnitz-Kustner titers of different sera should be carried out on a same reccipient, and it was demonstrated by P-K test that threshold of skin reactions in asthmatic patient was significantly correlated to the amount of reagin in the serum. Blocking antibody was tested during hyposensitization in ten asthmatic patients. The relationship between changes in threshold and blocking antibody titer suggested a possibility that hyposensitization caused production of blocking antibody, consumption and production of reagin. As the consequence of these possible reactions, threshold values and intensity of the standard skin reaction would change, however the former showed more sensitive change than the latter.
日本アレルギー学会の論文
1966-03-30

気管支喘息患者における室内塵抗原液皮内反応陽性限界濃度 (閾値)の研究およびPrausnitz-Kustner 反応の検討

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