腎における抗原抗体反応に関する研究 : 第1編.抗腎髄質血清の影響について.
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概要
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Continuing the investigation of the previous report, the author divided the kidney of rabbit into two portion, which was cortical portions and medullar ones. Anti-renal medulla sera were produced in guinea pigs by intraperitoneal injection of suspensions os blood free medullar portions of rabbit kidneys. The nephrotoxin of these sera were injected into the pregnant rabbits intravenously. One day, and one or two weeks after the injection these rabbits were sacrificed and investigated about histological changes in the kidneys. On a majority of the animals, remarkable changes in the kidney were observed as follows. 1) anemia and hyaline thrombosis in the glomerular loops. 2) swelling, degeneration and proliferation of the glomerular mesangial cells. 3) adhesions of glomerular loops and eosinophilic substances in the Bowman's capsuled. 4) degeneration of tubular epithelium and hyaline casts in the tubules. Similar renal changes to these diffuse glomerulitis with nephrotic changes were observes on the previous experiments by Takagi and Irino using anti-renal cortex serum of the rabbits. The results of the author's experiments suggest the existence of antigenicity in the medullar parts of the kidneys.
- 一般社団法人日本アレルギー学会の論文
- 1968-03-28