Behcet症候群に関する実験的研究
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概要
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Ocular lesion is one of the frequent findings (over 80%) of the Behcet's syndrome and recently plays an important role in the causes of blindness in Japan. But the digestive tract is the most frequently affected site (98%) and oral aphtha is the most frequent initial symptom (58%). Intestinal abnormalities are proved by X-ray investigation in about 80%. Ocular lesion develops mostly later. Therefore, in view of the clinical features and laboratory findings in Behcet's syndrome experiments were designed using homogenate of the intestinal mucosa and Esherichia coli emulsified in incomplete Freund's adjuvant (Drakeol and Arlacel A) to sensitize rabbits once every week prolongedly. Rabbits of control group were sensitized either with E-coli and incomplete Freund's adjuvant or with homogenate of the intestinal mucosa and incomplete Freund's adjuvant. In 2-9 months 7 of the 10 rabbits showed disorders such as protrusion of the eye and opacity of the cornea. Only one of the 12 control group rabbits, sensitized by E-coli with incomplete Freund's adjuvant, showed a similar but very slight eye protrusion. Histologically round cell infiltration of the ciliary body, a marked perivascular edema and slight infiltration of the optic nerve were revealed. The hyaline change and amyloid deposition were proved in the glomeruli of these rabbits. Further, pericholangiolitic cell infiltration in the liver and slight submucosal cell infiltration in the intestine were observed. Inerstitial pneumonitis was observed but also in the control group. FITC labeled anti-rabbit-gammaglobulin-goat serum showed presence of bound gamma globulin at these lesions. Serologically rheumatoid factor like substance became positive in some sera of the rabbits immunized by E-coli with or without homogenate of intestinal mucosa. No positive results were proved by intracutaneous test on the above rabbits and by agar gel precipitation test (Ouchterlony technique) with the sera of the rabbits using extract of the intestinal mucosa as antigen. With tanned cell hemagglutination technique (sensitization with E-coli extract) a significant rise of anti E-coli antibody titer was proved in the sera of Behcet's disease patients. But intracutaneous reaction with coli-extract and Schwartzman filtrate of E-coli culture showed not significant change in Behcet's disease. Behcet's syndrome in man has no marked kidney change as shown in the above experiment. But the above mentioned result suggests a possible role of the normal or usual intestinal flora and digestive tract change in the development of the multiple manifestation of Behcet's disease.
- 日本アレルギー学会の論文
- 1968-01-30
著者
関連論文
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