細菌アレルギーの立場よりみた気管支喘息の臨床的研究
スポンサーリンク
概要
- 論文の詳細を見る
Vaccine, substance containing the destructed protoplasma of bacilli(S.D.P.) and substance containing both the destructed protoplasma and dissolved cell wall of bacilli(S.D.P.W.) were made from the bacilli, which were isolated culturing the sputa of the patients with bronchial asthma of the infectious type or the allergic infectious type. The allergenicity of these bacterial substances were studied in asthmatics giving the results as follows: 1) The mean amount of protein in the S.D.P. as well as the S.D.P.W. was respectively 2.6 and 2.3 times as much as the amount of protein in the vaccine. However, as to the amount of glucose, there were only little differences among these three bacterial substances. 2) Taking statistically the results of skin test into regard, in immediate reaction, occurrence of erythema more than 14mm in diameter and in delayed reaction, the same more than 10 mm was respectively judged to be positive. Judging of the results thus made the incidence of positive skin test was noted to be obviously higher in the asthmatics than in the healthy individuals. 3) In the asthmatics skin test with heterovaccine in the great majority gave positive results in more than two species of bacilli, however skin test with autovaccine mostly gave positive results in only one species of bacilli. From these facts autovaccine was considered to be significant as a single antigen. 4) Comparing the results of skin test with these three bacterial substances, while autovccaine showed a delayed type of reaction, both auto- S.D.P. and auto- S.D.P.W. revealed an immediate type of reaction. 5) The inhalation test with three bacterial substances were performed in twenty-two asthmatics. While there was no noticeable positive reaction with the autovaccine, there were eight positive cases with the auto- S.D.P. and five with the auto- S.D.P.W. 6) Among the eight asthmatics, who showed positive inhalation test with the auto- S.D.P., six demonstrated positively the immediate type reaction and two showed positively the delayed type of the reaction in the skin test. With the Prausnitz-Kustner reaction, seven of the cases revealed positive results. 7) Nine asthmatics, who showed positive skin test with the auto-S.D.P., were given a hyposensitization treatment with the corresponding S.D.P. for one to two years. In four of these patients the hyposensitization treatment was noted to give favorable effect.
- 日本アレルギー学会の論文
- 1967-02-28
著者
関連論文
- 気管支喘息患者の切除肺における病理組織像と肺ヒスタミン値について
- 1) アレルゲン皮内反応判定基準の定め方に関する一考察 : とくにヘテロ加熱死菌ワクチンについて(第3回 東北アレルギー懇話会 第1回岩手アレルギー懇話会)
- 10) 気管支喘息患者の統計的観察 (第1報)(第2回 東北アレルギー懇話会)
- 9.老年喘息の知見(アレルゲン研究会記録 東北アレルギー懇話会)
- 細菌アレルギーの立場よりみた気管支喘息の臨床的研究
- 三陸沿岸のカキのむき身従業者のアレルギー調査