アナフィラキシー・ショック時の循環動態(<シンポジウム>I ショック)

概要

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About 70 dogs were sensitized and provoked to anaphylactic shock by the intravenous injection of horse serum. In this paper the following hemodynamic changes during anaphylactic shock were discussed. 1) Systemic hemodynamics: arterial pressure, inferior vena caval pressure, cardiac output, total peripheral resistance, circulating blood volume, central blood volume, systemic circulation time. circulation time from femoral vein to femoral artery, and electrocardiogram. 2) Hepatic circulation: hepatic blood flow, portal pressure, splanchnic resistance, splanchnic oxygen utilization, and blood oxygen content in hepatic vein and artery and portal vein. 3) Extravasation of plasma albumin: hematocrit value, plasma protein fraction, circulating red cell volume and plasma volume, Evans blue space, and erythrocytes and plasma albumin distribution in various organs (brain, lungs, heart, liver, spleen, stomach, small and large intestine, and kidneys). 4) Concentration of arterial blood catecholamines (adrenaline and noradrenaline). 5) Effects on the hemodynamic changes of chlorpromazine, adrenaline, tripelennamine, prednisolone, and dexamethasone. Analyzing above mentioned hemodynamic changes, it should be emphasized that the basic hemodynamic changes during anaphylactic shock are attributable to two major factors, contraction of the smooth muscle and increased vascular permeability.
日本アレルギー学会の論文
1967-01-25