リウマチ因子の研究 : リウマチ因子の各種動物のγ-グロブリンとの反応性について

概要

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With the aim of examining the reactivity of rheumatoid factor with gamma globulin of the ten kinds of animal, namely, human, rabbit, equine, bovine, guinea pig, rat, dog, chicken, goat, and sheep, the following results were obtained from the "tannic acid treated hemagglutination test" and "hemagglutination inhibition test with gamma globulin", and also "the absorption test of rheumatoid factor with insoluble gamma globulin treated by bisdiazotized benzidine". 1) Rheumatoid factor both in sera of rheumatoid arthritis and in sera of liver cirrhosis somewhat reacted with 7S gamma globulin of various kinds of animal, and it was shown that there was a tendency for the intensity of its cross reactivity to differ according to the sera used. 2) The rheumatoid factor which reacted with equine and rabbit gamma globulin in bisdiazotized benzidine treated gamma globulin column chromatography, also reacted with human gamma globulin, but there did not exist such a rheumatoid factor that only reacted with equine or rabbit gamma globulin. 3) Generally speaking, in "the inhibiton test against tannic acid treated hemagglution test, the same kind of gamma globulin as that used as reactant, showed the most intense inhibition.
日本アレルギー学会の論文
1966-01-30