4.マムシ毒に含まれるブラディキニン活性増強ペプチドの構造(第4回プラスマキニン研究会)

概要

論文の詳細を見る
It has recently been shown that the contractile action of bradykinin on isolated smooth muscles is potentiated by vatious substances, such as dimercapral, cysteine, thioglycolic acid, glutathione and some fibrinopeptides. Proteolytic enzymes, such as chymotrypsin and trypsin sensitize smooth muscle to bradykinin. We isolated the bradykinin-potentiating factors from the venom of Agkistrodon halys blomooffii (trivial name "Mamushi") and studied on the structure of one of the potentiators. Partial structure of one of the potentiators is shown as follows; (Glu, Gly, Leu, Pro_3, Arg)-Lys-Ile-Pro-Pro. The structural relation between potentiators and bradykinin seems interesting, because of their high proline content.
日本アレルギー学会の論文
1970-08-30