緑膿菌精製内毒素によるウサギ脳のArthus型病変

概要

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The pathological change corresponding to Arthus phenomenon was successfully produced in the rabbit brain in high precentage in both actively and passively sensitized rabbits by improved method of injections of Pseudomonas aeruginosa endotoxin. In actively sensitized rabbits the eliciting injection of the purified endotoxin in physiological saline into cisterna cerebellomedularis could be made effective in Arthus phenomenon sufficiently to produce such a pathological change as observed. The more repeated the eliciting injections, the more severe pathological changes were provocated. In passively sensitized rabbits with repeated intracisterna cerebellomedularis injections of the rabbit antitoxin serum, the eliciting intracisterna injection of the endotoxin 18-20 hours after the last sensitizing injection, was effective to produce severe pathological changes. Severe shock sympotoms were observed in both passively and actively sensitized rabbits in a few minutes after the eliciting injection. In some cases relaxing paralysis was found several hours later. Histologically, plasmastasis, fibrinoid-degeneration of vessel walls, hemorrhages, sever meningitis and inflamation of the choreoid plexuses, ependymitis, sera exsudation and cell infiltration around vessel walls and demyelinization were observed.
日本アレルギー学会の論文
1960-05-01